引用本文:
杨振云, 韩秀文, 胡皆汉, 陈惠林. 几种生物碱铂(Ⅱ)络合物的1H、13C-NMR研究[J]. 物理化学学报,
1988, 4(01): 32-36.
doi:
10.3866/PKU.WHXB19880107
Citation: Yang Zhenyun*, Han Xiuwen, Hu Jiehan, Chen Huilin. THE 1H, 13C-NMR STUDIES ON ALKALOID PLATINUM(Ⅱ) COMPLEXES[J]. Acta Physico-Chimica Sinica, 1988, 4(01): 32-36. doi: 10.3866/PKU.WHXB19880107
Citation: Yang Zhenyun*, Han Xiuwen, Hu Jiehan, Chen Huilin. THE 1H, 13C-NMR STUDIES ON ALKALOID PLATINUM(Ⅱ) COMPLEXES[J]. Acta Physico-Chimica Sinica, 1988, 4(01): 32-36. doi: 10.3866/PKU.WHXB19880107
几种生物碱铂(Ⅱ)络合物的1H、13C-NMR研究
摘要:
本文测定了具有抗癌活性的咖啡咽铂、茶碱铂、可可碱铂络合物的~1H和~(13)C-NMR谱,考察了络合前后生物碱配体~1H和~(13)C化学位移的变化,结合氢-铂、碳-铂偶合常数的测定,确定了各生物碱配位原子为咪唑环上双键氮,应用核磁共振技术搞清了与一般抗癌铂类络合物结构不同的咖啡咽铂等络合物的结构,并用异核选择去偶双共振技术对全部~(13)C和~1H谱线进行了归属。
English
THE 1H, 13C-NMR STUDIES ON ALKALOID PLATINUM(Ⅱ) COMPLEXES
Abstract:
The ~(13)C and ~1H NMR spectra of antitumor alkaloid platinum complexes such as caffeine, theophylline and theobromine platinum (Ⅱ)complexes were recorded. The ~1H, ~(13)C chemical shifts and carbon-hydrogen coupling constants were obtained for these alkaloids and their platinum complexes. Comparing the variations of δ_H and δ_C in the ligands before and after coordination and combining with the determination of carbon-platinum and hydrogen-platinum coupling constants, we find that the alkaloids coordinate to platinum unidentately, the coordination site is the double bond nitrogen atom on the five membered imidazole ring. The platinum (II) is coordinated with three chloride anions and one alkaloid ligand to form a mononuclear complex anion (PtLCl_3)~-. By heteronuclear proton selected decoupling technique, all the ~1H and ~(13)C NMR spectral lines were assigned.
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