引用本文:
李雅, 申利红, 王建森, 韩士田. 5-氟尿嘧啶-1-烷氧苯基三间氯苯基卟啉的合成及其体外抗癌活性[J]. 应用化学,
2013, 30(1): 38-42.
doi:
DOI:10.3724/SP.J.1095.2013.20012
Citation: LI Ya, SHEN Lihong, WANG Jiansen, HAN Shitian. Synthesis and Antitumor Activity in Vitro of 5-Fluorouracil-1-alkylaxgphenyl-tetra m-Chlorophenyl Porphyrin Compounds[J]. Chinese Journal of Applied Chemistry, 2013, 30(1): 38-42. doi: DOI:10.3724/SP.J.1095.2013.20012
Citation: LI Ya, SHEN Lihong, WANG Jiansen, HAN Shitian. Synthesis and Antitumor Activity in Vitro of 5-Fluorouracil-1-alkylaxgphenyl-tetra m-Chlorophenyl Porphyrin Compounds[J]. Chinese Journal of Applied Chemistry, 2013, 30(1): 38-42. doi: DOI:10.3724/SP.J.1095.2013.20012
5-氟尿嘧啶-1-烷氧苯基三间氯苯基卟啉的合成及其体外抗癌活性
English
Synthesis and Antitumor Activity in Vitro of 5-Fluorouracil-1-alkylaxgphenyl-tetra m-Chlorophenyl Porphyrin Compounds
Abstract:
To search for more potential antitumor agents,five new porphyrin-5-fluorouracil compounds were designed and synthesized.The reaction conditions were optimized and the separation method of the target products was explored.The compositions and structures of these compounds were confirmed by IR,UV-Vis,1H NMR and MS.Their cytotoxicity against five human cancer cell lines in vitro was evaluated by MTT assay.Biological screening results demonstrate that some tested compounds exhibit potential antitumor activity,particularly,compound D3 shows more potential cytotoxic activities than the control 5-fluorouracil against Sk-ov-3 cells.
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Key words:
- tetraphenyl porphyrin
- / fluorouraci derivatives
- / synthesis
- / antitumor activity in vitro
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