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N-邻苯二甲酰甘氨酸双核铜(Ⅱ)配合物的合成、晶体结构及与DNA的作用

韩向斌 ,  邵颖 ,  沈永淼

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引用本文: 韩向斌, 邵颖, 沈永淼. N-邻苯二甲酰甘氨酸双核铜(Ⅱ)配合物的合成、晶体结构及与DNA的作用[J]. 无机化学学报, 2013, 29(12): 2643-2648. doi: 10.3969/j.issn.1001-4861.2013.00.400 shu
Citation:  HAN Xiang-Bin, SHAO Ying, SHEN Yong-Miao. Synthesis, Crystal Structure and DNA-Binding Properties of Binuclear Copper(Ⅱ) Complex with N-Phthaloylglycinate[J]. Chinese Journal of Inorganic Chemistry, 2013, 29(12): 2643-2648. doi: 10.3969/j.issn.1001-4861.2013.00.400 shu

N-邻苯二甲酰甘氨酸双核铜(Ⅱ)配合物的合成、晶体结构及与DNA的作用

  • 基金项目:

    浙江省自然科学基金(No.Y508308) (No.Y508308)

    江苏省新型环保重点实验室(No.AE201306)资助项目。 (No.AE201306)

摘要: 合成了新的双核铜(Ⅱ)配合物：[Cu2(DMSO)2(ODPA)4]·2DMSO(其中，DMSO=二甲基亚砜，ODPA=N-邻苯二甲酰甘氨酸)。通过X-射线单晶衍射测定了该配合物的结构。配合物晶体属于三斜晶系，空间群P1，晶胞参数：a=1.036 1(2) nm，b=1.127 3(2) nm，c=1.212 6(2) nm，α=84.084(2)°，β=81.765(3)°，γ=82.163(2)°；晶胞体积V=1.383 6(4) nm3，晶胞结构基元数Z=1，Dc=1.508 g·cm-3，最后的残差因子：R=0.075 0，wR2=0.192 7。用紫外和荧光光谱等方法研究了配合物与DNA的相互作用。结果表明，配合物以部分插入方式与DNA作用，凝胶电泳实验结果表明，该配合物能够切割pBR322 DNA成Form Ⅱ。

English

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  • 收稿日期:  2013-05-21
  • 网络出版日期:  2013-07-30
通讯作者: 陈斌, bchen63@163.com
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