硅烷偶联剂制备及对磷灰石-硅灰石生物玻璃陶瓷的表面改性

引用本文: 龙沁, 周大利, 张翔, 卫冬娟, 柳淑婧, 陈冬宁. 硅烷偶联剂制备及对磷灰石-硅灰石生物玻璃陶瓷的表面改性[J]. 无机化学学报, 2013, 29(5): 948-952. doi: 10.3969/j.issn.1001-4861.2013.00.147 shu

Citation: LONG Qin, ZHOU Dali, ZHANG Xiang, WEI Dong-Juan, LIU Shu-Jing, CHEN Dong-Lin. Preparation of a Silane Coupling Agent and Surface Modification of Apatite-Wollastonite Bioactive Glass-Ceramic[J]. Chinese Journal of Inorganic Chemistry, 2013, 29(5): 948-952. doi: 10.3969/j.issn.1001-4861.2013.00.147 shu

硅烷偶联剂制备及对磷灰石-硅灰石生物玻璃陶瓷的表面改性

通讯作者: 周大利,E-mail:zdl@scu.edu.cn,lq773@scu.edu.cn

基金项目:
四川大学2011年青年基金(No.2082604154120)资助项目。 (No.2082604154120)

摘要: 采用谷氨酸与硅烷偶联剂(KH-792)缩合反应,制备出一种含酰胺基的硅烷偶联剂,利用其与材料之间的化学结合,将谷氨酸共价固定至磷灰石-硅灰石生物玻璃陶瓷表面,实现表面改性。将改性后的磷灰石-硅灰石生物玻璃陶瓷与人骨肉瘤细胞MG63共培养,评价其体外细胞生物相容性。应用FTIR、SEM、XPS等测试技术分别对合成的偶联剂、改性后的陶瓷材料进行结构、表面形貌及细胞生长情况的表征,结果表明:谷氨酸与KH-792的反应产物有酰胺基生成;含酰胺基的硅烷偶联剂能对磷灰石-硅灰石生物玻璃陶瓷表面进行有效改性;共培养3 d后细胞在材料材料表面大量贴附,MTT实验也证明增殖良好,即含酰胺基的硅烷偶联剂能改善磷灰石-硅灰石生物玻璃陶瓷的体外细胞生物相容性。

关键词:

硅烷偶联剂;谷氨酸;磷灰石-硅灰石生物玻璃陶瓷;表面改性

English

Preparation of a Silane Coupling Agent and Surface Modification of Apatite-Wollastonite Bioactive Glass-Ceramic

1.
College of Materials Science and Engineering, Sichuan University, Chengdu 610064, China

Corresponding author: 周大利,E-mail:zdl@scu.edu.cn,lq773@scu.edu.cn

Received Date: 19 October 2012
Fund Project:
四川大学2011年青年基金(No.2082604154120)资助项目。

Abstract: In this work, a kind of silane coupling agent was prepared by condensation reaction of the glutamic acid and silane coupling agent (KH-792). The Glutamic acid was attached to the surface of Apatite-wollastonite bioactive glass-ceramic (A-W GC) by the bifunctional cross-linking agent. To evaluate in vitro cytocompatibility, the surface modified material was co-cultured with the 5th generation human osteosarcoma cell MG63. Fourier Transform infrared spectroscopy (FTIR), Scanning Electron Microscope (SEM), and X-ray Photoelectron Spectroscopy (XPS) were used to character the structure and performance of the synthetic coupling agent and the surface modified A-W GC, respectively. The results show that the Glutamic acid and KH-792 were connected by amide groups, and A-W GC is effectively modified by the synthetic coupling agent. The MG63 cell experiments show that cells adhered to the surface of the material, and the cell proliferation on the surface of the material was promoted. It is an effective method to improve the cell compatibility of A-W GC by surface modification.

Key words:

silane coupling agent;glutamic acid;apatite-wollastonite bioactive glass-ceramic;surface modification

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1.
沈阳化工大学材料科学与工程学院沈阳 110142

硅烷偶联剂制备及对磷灰石-硅灰石生物玻璃陶瓷的表面改性

通讯作者: 周大利,E-mail:zdl@scu.edu.cn,lq773@scu.edu.cn

English

Preparation of a Silane Coupling Agent and Surface Modification of Apatite-Wollastonite Bioactive Glass-Ceramic

Corresponding author: 周大利,E-mail:zdl@scu.edu.cn,lq773@scu.edu.cn

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

硅烷偶联剂制备及对磷灰石-硅灰石生物玻璃陶瓷的表面改性

通讯作者: 周大利,E-mail:zdl@scu.edu.cn,lq773@scu.edu.cn

English

Preparation of a Silane Coupling Agent and Surface Modification of Apatite-Wollastonite Bioactive Glass-Ceramic

Corresponding author: 周大利,E-mail:zdl@scu.edu.cn,lq773@scu.edu.cn

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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