结石患者和健康对照者尿微晶生长、聚集过程的比较研究

引用本文: 柳一鸣, 夏志月, 欧阳健明, 贾丽萍, 张广娜, 丁一鸣. 结石患者和健康对照者尿微晶生长、聚集过程的比较研究[J]. 无机化学学报, 2013, 29(5): 903-909. doi: 10.3969/j.issn.1001-4861.2013.00.093 shu

Citation: LIU Yi-Ming, XIA Zhi-Yue, OUANG Jian-Ming, JIA Li-Ping, ZHANG Guang-Na, DING Yi-Ming. Comparative Study of Growth and Aggregation Process of Urinary Crystallites in Urines of Stone Patients and Healthy Controls[J]. Chinese Journal of Inorganic Chemistry, 2013, 29(5): 903-909. doi: 10.3969/j.issn.1001-4861.2013.00.093 shu

结石患者和健康对照者尿微晶生长、聚集过程的比较研究

通讯作者: 欧阳健明,E-mail:toyjm@jnu.edu.cn

基金项目:
国家自然科学基金(NO.81170649) (NO.81170649)

湖南省自然科学基金(No.S2012J5042) (No.S2012J5042)

湖南省教育厅科研项目(No.12C0702)资助项目。 (No.12C0702)

摘要: 采用扫描电子显微镜(SEM)和X-射线粉末衍射仪(XRD)比较研究了5例泌尿系结石患者和5名健康对照者的尿微晶的生长动力学差异。随着生长时间(t)增加,结石患者尿微晶尺寸不断增大,粒径从t=1 h时的约(6±4) μm增加到t=48 h的(29±17) μm,但微晶数密度从(1 400±300) mm^-2逐渐减少至(450±140) mm^-2,表明在患者尿液中微晶的形成过程为生长控制;相比之下,在对照者尿液中,随着t从1 h增加48 h,尿微晶数密度从(850±260) mm^-2减少至(610±210) mm^-2,微晶尺寸从(6±5) μm增加至(15±9) μm,这表明其生长过程同时为成核控制和生长控制。上述差异归因于对照者尿液中抑制剂的浓度和活性均比结石患者的高,更能抑制尿微晶的生长和聚集。

关键词:

尿微晶;动力学;SEM;XRD;肾结石

English

Comparative Study of Growth and Aggregation Process of Urinary Crystallites in Urines of Stone Patients and Healthy Controls

1.
1. Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang, Hunan 414000, China;

Corresponding author: 欧阳健明,E-mail:toyjm@jnu.edu.cn

Received Date: 07 August 2012
Fund Project:
国家自然科学基金(NO.81170649)

湖南省自然科学基金(No.S2012J5042)

湖南省教育厅科研项目(No.12C0702)资助项目。

Abstract: The differences in growth kinetics of urinary crystallites from 5 patients with renal stones and 5 healthy subjects were compared by using scanning electron microscopy (SEM) and X-ray diffractometer (XRD). With the increase of crystal growth time (t), the size of urinary crystallites from patients with renal stones increased constantly from (6±4) μm at t=1 h to (29±17) μm at t=48 h, but the density of crystallites decreased gradually from (1 400±300) mm^-2 at t=1 h to (450±140) mm^-2 at t=48 h. It indicated that the formation process of crystallites in lithogenic urine was dominated by growth control. In contrast, for healthy subjects, the density of urinary crystallites dereased from (850±260) mm^-2 at t=1 h to (610±210) mm^-2 at t=48 h, and the crystal size was increased only from 6±5 μm at t=1 h to (15±9) μm at t=48 h. It indicated that the growth process of crystallites in healthy urine was growth control and nucleation-control simultaneously. The differences mentioned above are mainly attributed to that both the concentration and activity of the inhibitors in healthy urine were higher than those in lithogenic urine, and thus can inhibit the growth and aggregation of urinary crystallites more effectively.

Key words:

urinary crystallites;kinetics;SEM;XRD;renal stones

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沈阳化工大学材料科学与工程学院沈阳 110142

结石患者和健康对照者尿微晶生长、聚集过程的比较研究

通讯作者: 欧阳健明,E-mail:toyjm@jnu.edu.cn

English

Comparative Study of Growth and Aggregation Process of Urinary Crystallites in Urines of Stone Patients and Healthy Controls

Corresponding author: 欧阳健明,E-mail:toyjm@jnu.edu.cn

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

结石患者和健康对照者尿微晶生长、聚集过程的比较研究

通讯作者: 欧阳健明,E-mail:toyjm@jnu.edu.cn

English

Comparative Study of Growth and Aggregation Process of Urinary Crystallites in Urines of Stone Patients and Healthy Controls

Corresponding author: 欧阳健明,E-mail:toyjm@jnu.edu.cn

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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