Abstract: Principles of chemical engineering serving as a bridge between basic and professional courses of chemical engineering plays a great role in the training of chemical talents. Based on the educational output concept of engineering education professional certification, we take the advantages of online and offline teaching, and carry out the exploration of online and offline collaborative teaching mode of chemical engineering principles. By constructing the collaborative teaching process, including "online pre-class preview and feedback, case reconstruction of teaching design for key and difficult points, task leading teaching interaction, post-class consolidation and expansion, and learning situation statistics", teachers and students can effectively interact online and offline, which strengthens teachers' control over the teaching process and improves students' learning initiative. By introducing online and offline comprehensive assessment method focusing on process evaluation, students' absorption and internalization of the teaching content can be improved.