Abstract: A series of acrylic ester resins with different pore structures was synthesized by varying the type and the amount of monomers,crosslinkers and pore-forming agents.Among of them,resin 1^# polymerized by trimethylolpropanetrimethacrylate(TRIM) with suitable pore distribution structure,resin 5^# by TRIM and triallylisocyanurate(TAIC) with amide groups,and the commercial macroporous acrylic resin XAD-7 were used to study the adsorption behavior of tylosin and the mechanism on acrylic ester resins. The resin 1^# exhibited a better adsorption property toward adsorbate. Similar patterns of pH-dependent adsorption showed that the adsorption amounts of tylosin increased with the increase pH values. The amounts of tylosin adsorbed increased in the presence of NaCl while decreased with CuCl₂ because of the dominant contribution of hydrophobic effect and size-exclusion effect. The adsorption kinetics of the three adsorbents followed the pseudo-second order model,while the adsorption isotherm data fit well to the Langmuir models,indicating the coverage of the surface by a mono-molecular layer. The apparent temperature influence on the adsorption process demonstrated that the "solvent replacement" was the dominant mechanism.