引用本文:
陈永师, 林建国, 邱玲, 程文, 罗世能, 马海霞. 三羰基锝配体基苯基甲磺酰胺的合成与表征[J]. 应用化学,
2012, 29(7): 757-761.
doi:
10.3724/SP.J.1095.2012.00333
Citation: CHEN Yongshi, LIN Jianguo, QIU Ling, CHENG Wen, LUO Shineng, MA Haixia. Synthesis and Characterization of Phenylmethanesulfonamide Ligand for Potential Labeling [99mTc(CO)3(H2O)3]+[J]. Chinese Journal of Applied Chemistry, 2012, 29(7): 757-761. doi: 10.3724/SP.J.1095.2012.00333
Citation: CHEN Yongshi, LIN Jianguo, QIU Ling, CHENG Wen, LUO Shineng, MA Haixia. Synthesis and Characterization of Phenylmethanesulfonamide Ligand for Potential Labeling [99mTc(CO)3(H2O)3]+[J]. Chinese Journal of Applied Chemistry, 2012, 29(7): 757-761. doi: 10.3724/SP.J.1095.2012.00333
三羰基锝配体基苯基甲磺酰胺的合成与表征
English
Synthesis and Characterization of Phenylmethanesulfonamide Ligand for Potential Labeling [99mTc(CO)3(H2O)3]+
Abstract:
A new ligand N-[2-cyclohexylmethoxy-4(1-(2,2'-bipyridinemethyl)amino)acetylamino] phenylmethanesulfonamide(NSC-PA),for potential labeling [99mTc(CO)3(H2O)3]+ was synthesized by hydroxyl-alkylation,amino-methylsulfonylation,nitro-reduction,amino-bromideacetylation and N-alkylation from 2-amino-5-nitrophenol.Simple experimental operation,short period and purified products could be obtained under optimized conditions.The structures of all the compounds were confirmed by 1H NMR,IR and MS.The purity of the target compound was over 98% as given by HPLC result.The target product could be used for future labeling studies.This synthesis is promising in the exploration of new imaging reagent for breast cancer.
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Key words:
- phenylmethanesulfonamide
- / synthesis
- / characterization
- / labeling ligand
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