引用本文:
赵地顺, 吕斌, 寇成, 杨洁, 董兰芬, 张妍. 激光法测定硝唑尼特结晶介稳区间[J]. 应用化学,
2011, 28(9): 1063-1066.
doi:
10.3724/SP.J.1095.2011.00610
Citation: ZHAO Dishun, LV Bin, KOU Cheng, YANG Jie, DONG Lanfen, ZHANG Yan. Measurement of Crystallization Metastable Zone of Nitazoxanide Using the Laser Scattering Method[J]. Chinese Journal of Applied Chemistry, 2011, 28(9): 1063-1066. doi: 10.3724/SP.J.1095.2011.00610
Citation: ZHAO Dishun, LV Bin, KOU Cheng, YANG Jie, DONG Lanfen, ZHANG Yan. Measurement of Crystallization Metastable Zone of Nitazoxanide Using the Laser Scattering Method[J]. Chinese Journal of Applied Chemistry, 2011, 28(9): 1063-1066. doi: 10.3724/SP.J.1095.2011.00610
激光法测定硝唑尼特结晶介稳区间
English
Measurement of Crystallization Metastable Zone of Nitazoxanide Using the Laser Scattering Method
Abstract:
The saturated and supersaturated characteristics of nitazoxanide in DMF, DMSO, methanol and acetone at different temperatures were investigated by using the laser detection technique. The crystallization metastable zone widths of nitazoxanide were obtained at different temperatures in the above four solvents. The results indicated that the solubility, supersolubility and the metastable zone width of nitazoxanide enhance with increasing temperature. At the same temperature, the metastable zone width of nitazoxanide relations as follows:acetone< DMSO< methanol< DMF.
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Key words:
- nitazoxanide
- / solubility
- / supersolubility
- / metastable zone width
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