引用本文:
冯小强, 李小芳, 杨声. 硫脲壳聚糖Co(Ⅱ)配合物的制备、抑菌活性及与血清白蛋白的作用[J]. 应用化学,
2011, 28(9): 1012-1016.
doi:
10.3724/SP.J.1095.2011.00375
Citation: FENG Xiaoqiang, LI Xiaofang, YANG Sheng. Preparation， Antibacterial Activities of Thiourea-chitosanCo(Ⅱ) Complex and Interaction with Bovine Serum Albumin[J]. Chinese Journal of Applied Chemistry, 2011, 28(9): 1012-1016. doi: 10.3724/SP.J.1095.2011.00375
Citation: FENG Xiaoqiang, LI Xiaofang, YANG Sheng. Preparation， Antibacterial Activities of Thiourea-chitosanCo(Ⅱ) Complex and Interaction with Bovine Serum Albumin[J]. Chinese Journal of Applied Chemistry, 2011, 28(9): 1012-1016. doi: 10.3724/SP.J.1095.2011.00375
硫脲壳聚糖Co(Ⅱ)配合物的制备、抑菌活性及与血清白蛋白的作用
摘要:
合成了硫脲壳聚糖Co(Ⅱ)配合物,运用红外光谱、紫外光谱和差热热重分析对配合物进行了表征,研究了其对大肠杆菌和金黄色葡萄球菌的抑菌性能及与血清白蛋白(BSA)的相互作用。结果表明,硫脲壳聚糖能与Co(Ⅱ)发生配位反应而生成硫脲壳聚糖-Co(Ⅱ)配合物,该配合物的抑菌性能较壳聚糖和硫脲壳聚糖有显著提高,并能有规律地猝灭BSA的内源荧光。
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关键词:
- 硫脲壳聚糖Co(Ⅱ)配合物
- / 抑菌性能
- / 血清白蛋白
English
Preparation， Antibacterial Activities of Thiourea-chitosanCo(Ⅱ) Complex and Interaction with Bovine Serum Albumin
Abstract:
Thiourea-chitosan-Co(Ⅱ) complex was prepared and characterized by FT-IR, UV-Vis absorbance spectra and TG-DTA methods, the antibacterial activities of thiourea-chitosan-Co(Ⅱ) complex against E.coli and St. aureus were studied in vitro. Moreover, the interaction between thiourea-chitosan-Co(Ⅱ) complex and bovine serum albumin(BSA) was also studied by ultraviolet and fluorescence spectroscopies. The results confirm that the complex is formed, and the antibacterial activities of thiourea-chitosan-Co(Ⅱ) complex is obviously enhanced comparing to its ligands and the complex can quench the intrinsic fluorescence of BSA.
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