引用本文:
赵胜芳, 陈年友, 张寒梅, 张京, 李早英. 新型取代胡椒醛缩合不对称卟啉金属配合物的微波合成及其抗菌活性[J]. 应用化学,
2015, 32(5): 542-546.
doi:
10.11944/j.issn.1000-0518.2015.05.140302
Citation: ZHAO Shengfang, CHEN Nianyou, ZHANG Hanmei, ZHANG Jing, LI Zaoying. Microwave Synthesis and Antibacterial Activity of Novel Asymmetric Porphyrin Matal Complexes from Substituted Piperonal[J]. Chinese Journal of Applied Chemistry, 2015, 32(5): 542-546. doi: 10.11944/j.issn.1000-0518.2015.05.140302
Citation: ZHAO Shengfang, CHEN Nianyou, ZHANG Hanmei, ZHANG Jing, LI Zaoying. Microwave Synthesis and Antibacterial Activity of Novel Asymmetric Porphyrin Matal Complexes from Substituted Piperonal[J]. Chinese Journal of Applied Chemistry, 2015, 32(5): 542-546. doi: 10.11944/j.issn.1000-0518.2015.05.140302
新型取代胡椒醛缩合不对称卟啉金属配合物的微波合成及其抗菌活性
摘要:
利用微波辐射加热方法合成了5-(3,4-亚甲二氧基-6-硝基)苯基-10,15,20-三苯基卟啉和5-(3,4-亚甲二氧基-6-硝基)苯基-10,15,20-三对氯苯基卟啉的Zn(Ⅱ)、Co(Ⅱ)、Mn(Ⅱ)金属配合物,产物的结构用紫外-可见光谱、红外光谱、荧光光谱等技术手段进行了表征,采用抑菌环方法研究了目标化合物对大肠杆菌和金黄色葡萄球菌的抗菌活性,实验结果表明,两个Co(Ⅱ)金属配合物在浓度为0.32 mmol/L时对Sa、Ec有较强的抑菌作用,浓度为0.02 mmol/L时还有一定的抑菌作用;2个Zn(Ⅱ)和2个Mn(Ⅱ)配合物在浓度为0.16~0.32 mmol/L范围内对Sa、Ec有中等强度的抑菌作用。各金属配合物的抑菌活性大小顺序大体为:Por(Co)>Por(Mn)≈Por(Zn)。各配合物对金黄色葡萄球菌的抑制作用比大肠杆菌大约高10%~20%。
English
Microwave Synthesis and Antibacterial Activity of Novel Asymmetric Porphyrin Matal Complexes from Substituted Piperonal
Abstract:
Zn(Ⅱ),Co(Ⅱ) and Mn(Ⅱ) complexes of 5-(2-nitro-4,5-methylenedioxy) phenyl-10,15,20-triphenyl-porphyrin and 5-(2-nitro-4,5-methylenedioxy) phenyl-10,15,20-tri(p-chlorophenyl)-porphyrin were synthesized by microwave irradiation.Their structures were characterized by UV-Vis,IR,fluoresence spectroscopies.The bactericidal activities of these metal compounds on Escherichia coli aureu(Ec) and Staphylococcusaureu(Sa) were studied with the inhibition ring test.These complexes show photosensitive antibacterial activities against these two bacteria.The Co(Ⅱ) complexes have obvious bacteriostatic activities against Ec and Sa at the concentration of 0.32 mmol/L and 0.02 mmol/L,respectively,and some bacteriostatic effects.The Zn(Ⅱ) and Co(Ⅱ) complexes have moderate antibacterial effects at 0.16~0.32 mmol/L.The order of the antibacterial activity of these complexes is Por(Co)>Por(Mn)≈Por(Zn).The bacteriostatic effects of the complexes on Ec are 10%~20% higher than those on Sa.
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Key words:
- asymmetrical porphyrin
- / metal complex
- / microwave synthesis
- / characterization
- / antibacterial activity
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