引用本文:
冯建华, 吴刚. 4,4',6,6'-四叔丁基-2,2'-[乙二氧双(氮次甲基)]二酚铜(Ⅱ)化合物的合成、结构及抑菌活性[J]. 应用化学,
2015, 32(5): 557-561.
doi:
10.11944/j.issn.1000-0518.2015.05.140287
Citation: FENG Jianhua, WU Gang. Synthesis, Structure and Antibacterial Activities of 4, 4', 6, 6'-Tetra(tert-butyl)-2, 2'-[ethylenedioxybis (nitrilomethylidyne)] diphenol and Its Cu(Ⅱ) Complex[J]. Chinese Journal of Applied Chemistry, 2015, 32(5): 557-561. doi: 10.11944/j.issn.1000-0518.2015.05.140287
Citation: FENG Jianhua, WU Gang. Synthesis, Structure and Antibacterial Activities of 4, 4', 6, 6'-Tetra(tert-butyl)-2, 2'-[ethylenedioxybis (nitrilomethylidyne)] diphenol and Its Cu(Ⅱ) Complex[J]. Chinese Journal of Applied Chemistry, 2015, 32(5): 557-561. doi: 10.11944/j.issn.1000-0518.2015.05.140287
4,4',6,6'-四叔丁基-2,2'-[乙二氧双(氮次甲基)]二酚铜(Ⅱ)化合物的合成、结构及抑菌活性
摘要:
在室温、无水乙醇溶剂中,H2L(H2L=4,4',6,6'-四叔丁基-2,2'-[乙二氧双(氮次甲基)]二酚)与一水合醋酸铜反应得到了一种新的铜(Ⅱ)化合物C32H46CuN2O4([CuL]),并通过红外光谱、元素分析及X射线单晶衍射等技术手段对[CuL]进行了表征。[CuL]的结构解析表明,属单斜晶系,空间群C2/c,晶胞参数为a=2.7231(3)nm,b=1.1196(3)nm,c=1.0704(2)nm,α=90.00°,β=101.293(2)°,γ=90.00°,V=3.2002(11)nm3,Z=4,Mr=586.25,Dc=1.217 g/cm3,μ=0.718mm-1,F(000)=1252,R1=0.0957,wR2=0.2297。[CuL]的对称单元中含有1个Cu(Ⅱ)原子和1个配位L分子组成,中心Cu(Ⅱ)的配位数为4,分别与来自L单元上的N1、N1#、O2、O2#4个原子进行配位,以金属离子为中心形成了稍微扭曲四面体结构的配位几何构型。对金黄色葡萄球菌、大肠杆菌和枯草杆菌的抑菌活性实验表明,[CuL]对3种菌均有显著的抑制作用,其抑菌活性较配体L更强。
English
Synthesis, Structure and Antibacterial Activities of 4, 4', 6, 6'-Tetra(tert-butyl)-2, 2'-[ethylenedioxybis (nitrilomethylidyne)] diphenol and Its Cu(Ⅱ) Complex
Abstract:
A novel Cu(Ⅱ) compound,C32H46 CuN2O4([CuL]),has been synthesized in ethanol by the reaction of H2L(H2L=4,4',6,6'-tetra(tert-butyl)-2,2'-[ethylenedioxybis(nitrilomethylidyne)]diphenol)with copper(Ⅱ) acetate monohydrate at room temperature and characterized by IR spectroscopy,elemental analyses and X-ray crystallography.The X-ray crystal structure of[CuL]crystallizes in a monoclinic system,space group C2/c,with a=2.7231(3) nm,b=1.1196(3) nm,c=1.0704(2) nm,α=90.00°,β=101.293(2) °,γ=90.00°,V=3.2002(11) nm3,Z=4,Mr=586.25,Dc=1.217 g/cm3,μ=0.718mm-1,F(000)=1252,R1=0.0957,wR2=0.2297.The symmetric unit in[CuL]contains one Cu(Ⅱ) atom and one coordinated L molecule.The central Cu(Ⅱ) atom are four-coordinated by N1,N1#,O2 and O2# atoms from the coordinated L unit.A slightly distorted tetrahedral geometry is formed around the central Cu(Ⅱ) atom.The antibacterial activities of H2L and[CuL] are investigated using K-B method,the results indicate that[CuL] has remarkable antibacterial effect on Staphylococcus aureus,Escherichia coli and Withered grass bacillus.[CuL] has stronger activities against the three bacterias than the H2L ligand.
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Key words:
- Cu(Ⅱ) complex
- / synthesis
- / structure
- / antibacterial activity
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