微流控芯片的研究及产业化

引用本文: 林炳承. 微流控芯片的研究及产业化[J]. 分析化学, 2016, 44(4): 491-499. doi: 10.11895/j.issn.0253-3820.160131 shu

Citation: LIN Bing-Cheng. Research and Industrialization of Microfluidic Chip[J]. Chinese Journal of Analytical Chemistry, 2016, 44(4): 491-499. doi: 10.11895/j.issn.0253-3820.160131 shu

微流控芯片的研究及产业化

林炳承 ^,

1.
中国科学院大连化学物理研究所, 大连 116023

通讯作者: 林炳承

摘要: 以大连研究团队的近期工作为基础,结合2015年末召开的"深圳-大连微流控芯片及其产业化战略研讨会"内容,扼要阐述作者对近期微流控芯片的研究及产业化的基本看法。鉴于微流控芯片研究的主流已从平台构建和方法发展转为不同领域的广泛应用,本文重点介绍了微流控芯片在现代生物化学分析、即时诊断、材料筛选-材料合成以及组织-器官仿生等4个应用领域的研究趋势,讨论了3D打印技术的崛起对微流控芯片的影响和挑战,阐述了微流控芯片作为当代极为重要的新兴科学技术平台和国家层面产业转型的潜在战略领域,在全球范围内产业化的发展势头。全文引用文献69篇。

关键词:

微流控芯片
/ 产业化
/ 综述

English

1. [1]
  1 LIN Bing-Cheng. Proceedings of the Shenzhen/Dalian Bilateral Conference on Microfluidics and Commercialization Strategy, 2015:6 林炳承. 深圳-大连微流控芯片及其产业化战略研讨会文集, 2015:61 LIN Bing-Cheng. Proceedings of the Shenzhen/Dalian Bilateral Conference on Microfluidics and Commercialization Strategy, 2015:6 林炳承. 深圳-大连微流控芯片及其产业化战略研讨会文集, 2015:6
2. [2]
  2 LIN Bing-Cheng. Micro/Nanofluidic Chip Laboratory, Beijing:Science Press, 2013:1-6 林炳承. 微纳流控芯片实验室. 北京:科学出版社, 2013:1-62 LIN Bing-Cheng. Micro/Nanofluidic Chip Laboratory, Beijing:Science Press, 2013:1-6 林炳承. 微纳流控芯片实验室. 北京:科学出版社, 2013:1-6
3. [3]
  3 Sjostrom S L, Bai Y, Huang M, Liu Z H, Nielsen J, Joensson H N, Svahn H A. Lab Chip, 2014, 14(4):806-8133 Sjostrom S L, Bai Y, Huang M, Liu Z H, Nielsen J, Joensson H N, Svahn H A. Lab Chip, 2014, 14(4):806-813
4. [4]
  4 Hümmer D, Kurth F, Naredi-Rainer N, Dittrich P S. Lab Chip, 2016, 16(3):447-4584 Hümmer D, Kurth F, Naredi-Rainer N, Dittrich P S. Lab Chip, 2016, 16(3):447-458
5. [5]
  5 Shi X B, Dong S L, Li M M, Liu X J, Zhang Q Q, Zhao W F, Zong C H, Zhang Y W, Gai H W. Chem. Commun., 2015, 51(12):2353-23565 Shi X B, Dong S L, Li M M, Liu X J, Zhang Q Q, Zhao W F, Zong C H, Zhang Y W, Gai H W. Chem. Commun., 2015, 51(12):2353-2356
6. [6]
  6 Fu Y S, Li C M, Lu S J, Zhou W X, Tang F C, Xie X S, Huag Y Y. Proc. Natl. Acad Sci. USA, 2015, 112(38):11923-119286 Fu Y S, Li C M, Lu S J, Zhou W X, Tang F C, Xie X S, Huag Y Y. Proc. Natl. Acad Sci. USA, 2015, 112(38):11923-11928
7. [7]
  7 Streets A M, Zhang X N, Cao C, Pang Y H, Wu X L, Xiong L,Yang L, Fu Y S, Zhao L, Tang F C, Huang Y Y. Proc. Natl. Acad Sci. USA, 2014, 111(19):7048-70537 Streets A M, Zhang X N, Cao C, Pang Y H, Wu X L, Xiong L,Yang L, Fu Y S, Zhao L, Tang F C, Huang Y Y. Proc. Natl. Acad Sci. USA, 2014, 111(19):7048-7053
8. [8]
  8 Lu Y, Xue Q, Eisele M R, Sulistijo E S, Kara B, Han L, El-ad David A, Dana Pe'er, Kathryn M J, Fan R. Proc. Natl. Acad Sci. USA, 2015, 112(7):E607-E6158 Lu Y, Xue Q, Eisele M R, Sulistijo E S, Kara B, Han L, El-ad David A, Dana Pe'er, Kathryn M J, Fan R. Proc. Natl. Acad Sci. USA, 2015, 112(7):E607-E615
9. [9]
  9 Xue Q, Lu Y, Eisele M R, Sulistijo E S, Khan N, Fan R, Miller-Jensen K. Sci. Signal., 2015, 8(381):ra599 Xue Q, Lu Y, Eisele M R, Sulistijo E S, Khan N, Fan R, Miller-Jensen K. Sci. Signal., 2015, 8(381):ra59
10. [10]
  10 Zhang P R, Ren L H, Zhang X, Shan Y F, Wang Y, Ji Y T, Yin H B, Huang W E, Xu J, Ma B. Anal. Chem., 2015, 87(4):2282-228910 Zhang P R, Ren L H, Zhang X, Shan Y F, Wang Y, Ji Y T, Yin H B, Huang W E, Xu J, Ma B. Anal. Chem., 2015, 87(4):2282-2289
11. [11]
  11 Li Y W, Feng X J, Du W, Li Y, Liu B F. Anal. Chem., 2013, 85(8):4066-407311 Li Y W, Feng X J, Du W, Li Y, Liu B F. Anal. Chem., 2013, 85(8):4066-4073
12. [12]
  12 Liu W, Wang N J, Lin X X, Ma Y, Lin J M. Anal. Chem., 2014, 86(14):7128-713412 Liu W, Wang N J, Lin X X, Ma Y, Lin J M. Anal. Chem., 2014, 86(14):7128-7134
13. [13]
  13 Steve C C S, Philip C G, Jess S, Blake A S, Paul D A. Lab Chip, 2015, 15:225-23613 Steve C C S, Philip C G, Jess S, Blake A S, Paul D A. Lab Chip, 2015, 15:225-236
14. [14]
  14 Gao J, Liu X M, Chen T L, Mark P I, Du Y G, Vai MI, Lin B C, Martins R P. Lab Chip, 2013, 13(3):443-45114 Gao J, Liu X M, Chen T L, Mark P I, Du Y G, Vai MI, Lin B C, Martins R P. Lab Chip, 2013, 13(3):443-451
15. [15]
  15 Srinivasan V, PamulaV K, Fair R B, Lab Chip, 2004, 4(4):310-31515 Srinivasan V, PamulaV K, Fair R B, Lab Chip, 2004, 4(4):310-315
16. [16]
  16 Mousa N A, Jebrail M J, Yang H, Abdelgawad M, Metalnikov P, Chen J, Wheeler A R, Casper R F. Sci. Transl. Med., 2009, 1(1):1ra216 Mousa N A, Jebrail M J, Yang H, Abdelgawad M, Metalnikov P, Chen J, Wheeler A R, Casper R F. Sci. Transl. Med., 2009, 1(1):1ra2
17. [17]
  17 Jebrail M J, Yang H, Mudrik J M, Lafrenière N M, McRoberts C, Al-Dirbashi O Y, Fisher L, Chakraborty P, Wheeler A R. Lab Chip, 2011, 11(19):3218-322417 Jebrail M J, Yang H, Mudrik J M, Lafrenière N M, McRoberts C, Al-Dirbashi O Y, Fisher L, Chakraborty P, Wheeler A R. Lab Chip, 2011, 11(19):3218-3224
18. [18]
  18 Sista R S, Eckhardt A E, Wang T, Graham C, Rouse J L, Norton S M, Srinivasan V, Pollack M G, Tolun A A, Bali D, Millington D S, Pamula V K.Clin. Chem., 2011, 57(10):1444-145118 Sista R S, Eckhardt A E, Wang T, Graham C, Rouse J L, Norton S M, Srinivasan V, Pollack M G, Tolun A A, Bali D, Millington D S, Pamula V K.Clin. Chem., 2011, 57(10):1444-1451
19. [19]
  19 Poulos J L, Nelson W C, Jeon T J, Schmidt J J. Appl. Phys. Lett., 2009, 95(1):01370619 Poulos J L, Nelson W C, Jeon T J, Schmidt J J. Appl. Phys. Lett., 2009, 95(1):013706
20. [20]
  20 TIAN Rui-Jun. Proceedings of the Shenzhen/Dalian Bilateral Conference on Microfluidics and Commercialization Strategy, 2015:29-30 田瑞军. 深圳-大连微流控芯片及其产业化战略研讨会文集,2015:29-3020 TIAN Rui-Jun. Proceedings of the Shenzhen/Dalian Bilateral Conference on Microfluidics and Commercialization Strategy, 2015:29-30 田瑞军. 深圳-大连微流控芯片及其产业化战略研讨会文集,2015:29-30
21. [21]
  21 Boles D J, Benton J L, Siew G J, Levy M H, Thwar P K, Sandahl M A, Rouse J L, Perkins L C, Sudarsan A P, Jalili R, Pamula V K, Srinivasant v, Fair R B, Griffin P B, Eckhardt A E, Pollack M G. Anal. Chem., 2011, 83(22):8439-844721 Boles D J, Benton J L, Siew G J, Levy M H, Thwar P K, Sandahl M A, Rouse J L, Perkins L C, Sudarsan A P, Jalili R, Pamula V K, Srinivasant v, Fair R B, Griffin P B, Eckhardt A E, Pollack M G. Anal. Chem., 2011, 83(22):8439-8447
22. [22]
  22 CHENG Xin. Proceedings of the Shenzhen/Dalian Bilateral Conference on Microfluidics and Commercialization Strategy, 2015:8 程鑫. 深圳-大连微流控芯片及其产业化战略研讨会文集, 2015:822 CHENG Xin. Proceedings of the Shenzhen/Dalian Bilateral Conference on Microfluidics and Commercialization Strategy, 2015:8 程鑫. 深圳-大连微流控芯片及其产业化战略研讨会文集, 2015:8
23. [23]
  23 Zhou X M, Liu D Y, Zhong R T, Dai Z P, Wu D P, Wang H, Du Y G, Xia Z N, Zhang L P, Mei X D, Lin B C. Electrophoresis, 2004, 25(17):3032-303923 Zhou X M, Liu D Y, Zhong R T, Dai Z P, Wu D P, Wang H, Du Y G, Xia Z N, Zhang L P, Mei X D, Lin B C. Electrophoresis, 2004, 25(17):3032-3039
24. [24]
  24 Ma B, Zhang G H, Qin J H, Lin B C. Lab Chip, 2009, 9(2):232-23824 Ma B, Zhang G H, Qin J H, Lin B C. Lab Chip, 2009, 9(2):232-238
25. [25]
  25 Weaver W, Kittur H, Dhar M, Di Carlo D. Lab Chip, 2014, 14(12):1962-196525 Weaver W, Kittur H, Dhar M, Di Carlo D. Lab Chip, 2014, 14(12):1962-1965
26. [26]
  26 Wei X F, Tian T, Jia S S, Zhu Z, Ma Y L, Sun J J, Lin Z Y, Yang CY. Anal. Chem., 2015, 87(8):4275-428226 Wei X F, Tian T, Jia S S, Zhu Z, Ma Y L, Sun J J, Lin Z Y, Yang CY. Anal. Chem., 2015, 87(8):4275-4282
27. [27]
  27 Hsu M Y, Yang C Y, Hsu W H, Lin K H, Wang C Y, Shen Y C, Chen Y C, Chau S F, Tsai H Y, Cheng C M. Biomaterials, 2014, 35(12):3729-373527 Hsu M Y, Yang C Y, Hsu W H, Lin K H, Wang C Y, Shen Y C, Chen Y C, Chau S F, Tsai H Y, Cheng C M. Biomaterials, 2014, 35(12):3729-3735
28. [28]
  28 Goldsmith B R, Mitala J J, Josue J, Castro A, Lerner M B, Bayburt T H, Khamis S M, Jones R A, Brand J G, Sligar S G, Luetje C W, Gelperin A, Rhodes P A, Discher B M, Johnson A T C. ACS Nano, 2011, 5(7):5408-541628 Goldsmith B R, Mitala J J, Josue J, Castro A, Lerner M B, Bayburt T H, Khamis S M, Jones R A, Brand J G, Sligar S G, Luetje C W, Gelperin A, Rhodes P A, Discher B M, Johnson A T C. ACS Nano, 2011, 5(7):5408-5416
29. [29]
  29 Lim J H, Park J, Oh E H, Ko H J, Hong S, Park T H. Adv. Healthc. Mater., 2014, 3(3):360-36629 Lim J H, Park J, Oh E H, Ko H J, Hong S, Park T H. Adv. Healthc. Mater., 2014, 3(3):360-366
30. [30]
  30 Watkins N N, Hassan U, Damhorst G, Ni H K, Vaid A, Rodriguez W, Bashir R. Sci. Transl. Med., 2013, 5(214):214ra17030 Watkins N N, Hassan U, Damhorst G, Ni H K, Vaid A, Rodriguez W, Bashir R. Sci. Transl. Med., 2013, 5(214):214ra170
31. [31]
  31 LIU Da-Yu. Proceedings of the Shenzhen/Dalian Bilateral Conference on Microfluidics and Commercialization Strategy, 2015:33 刘大渔. 深圳-大连微流控芯片及其产业化战略研讨会文集, 2015:3331 LIU Da-Yu. Proceedings of the Shenzhen/Dalian Bilateral Conference on Microfluidics and Commercialization Strategy, 2015:33 刘大渔. 深圳-大连微流控芯片及其产业化战略研讨会文集, 2015:33
32. [32]
  32 Abate A R, Hung T, Sperling R A, Mary P, Rotem A, Agresti J J, Weiner M A, Weitz D A. Lab Chip, 2013, 13(24):4864-486932 Abate A R, Hung T, Sperling R A, Mary P, Rotem A, Agresti J J, Weiner M A, Weitz D A. Lab Chip, 2013, 13(24):4864-4869
33. [33]
  33 Guo M T, Rotem A, Heyman J A, Weitz D A. Lab Chip, 2012, 12(12):2146-215533 Guo M T, Rotem A, Heyman J A, Weitz D A. Lab Chip, 2012, 12(12):2146-2155
34. [34]
  34 Sciambi A, Abate A R. Lab Chip, 2015, 15(1):47-5134 Sciambi A, Abate A R. Lab Chip, 2015, 15(1):47-51
35. [35]
  35 Sjostrom S L, Bai Y, Huang M, Liu Z, Nielsen J, Joensson H N, Svahn H A. Lab Chip, 2014, 14(4):806-81335 Sjostrom S L, Bai Y, Huang M, Liu Z, Nielsen J, Joensson H N, Svahn H A. Lab Chip, 2014, 14(4):806-813
36. [36]
  36 Balaban N Q, Merrin J, Chait R, Kowalik L, Leibler S. Science, 2004, 305(5690):1622-162536 Balaban N Q, Merrin J, Chait R, Kowalik L, Leibler S. Science, 2004, 305(5690):1622-1625
37. [37]
  37 Yokoyama W M, Christensen M, Santos G D, Miller D. Current Protocols in Immunology. Hoboken. John Wiley & Sons Inc. 2006:Chapter 237 Yokoyama W M, Christensen M, Santos G D, Miller D. Current Protocols in Immunology. Hoboken. John Wiley & Sons Inc. 2006:Chapter 2
38. [38]
  38 Shields C W 4th, Reyes C D, López G P. Lab Chip, 2015, 15(15):1230-124938 Shields C W 4th, Reyes C D, López G P. Lab Chip, 2015, 15(15):1230-1249
39. [39]
  39 Zhu Y, Zhang Y X, Cai L F, Fang Q. Anal. Chem., 2013, 85(14):6723-673139 Zhu Y, Zhang Y X, Cai L F, Fang Q. Anal. Chem., 2013, 85(14):6723-6731
40. [40]
  40 Zhu Y, Zhu L N, Guo R, Cui H J, Ye S, Fang Q. Sci. Rep., 2014, 4:504640 Zhu Y, Zhu L N, Guo R, Cui H J, Ye S, Fang Q. Sci. Rep., 2014, 4:5046
41. [41]
  41 Zhu Y, Zhang Y H, Liu W W, Ma Y, Yao B, Fang Q, Sci. Rep., 2015, 5:955141 Zhu Y, Zhang Y H, Liu W W, Ma Y, Yao B, Fang Q, Sci. Rep., 2015, 5:9551
42. [42]
  42 Seo K D, Kim D S, Sánchez S. Lab Chip, 2015, 15(18):3622-362642 Seo K D, Kim D S, Sánchez S. Lab Chip, 2015, 15(18):3622-3626
43. [43]
  43 Zhang Q Q, Zeng S J, Lin B C,Qin J H. J. Mater Chem., 2011, 21(8):2466-246943 Zhang Q Q, Zeng S J, Lin B C,Qin J H. J. Mater Chem., 2011, 21(8):2466-2469
44. [44]
  44 Zhang Q Q, Lin B C, Qin J. Microfluid. Nanofluid., 2012, 12(1-4):33-3944 Zhang Q Q, Lin B C, Qin J. Microfluid. Nanofluid., 2012, 12(1-4):33-39
45. [45]
  45 Nisisako T, Ando T, Hatsuzawa T. Small, 2014, 10(24):5116-512545 Nisisako T, Ando T, Hatsuzawa T. Small, 2014, 10(24):5116-5125
46. [46]
  46 LI Chun-Lin. Proceedings of the Shenzhen/Dalian Bilateral Conference on Microfluidics and Commercialization Strategy, 2015:36 李春林. 深圳-大连微流控芯片及其产业化战略研讨会文集, 2015:3646 LI Chun-Lin. Proceedings of the Shenzhen/Dalian Bilateral Conference on Microfluidics and Commercialization Strategy, 2015:36 李春林. 深圳-大连微流控芯片及其产业化战略研讨会文集, 2015:36
47. [47]
  47 Huh D, Matthews B D, Mammoto A, Montoya-Zavala M, Hsin H Y, Ingber D E. Science, 2010, 328(5986):1662-166847 Huh D, Matthews B D, Mammoto A, Montoya-Zavala M, Hsin H Y, Ingber D E. Science, 2010, 328(5986):1662-1668
48. [48]
  48 NIH, DARPA and FDA Collaborate to Develop Cutting-edge Technologies to Predict Drug Safety,[sep 16th 2011], http://www.nih.gov/news/health/sep2011/od-16.htm48 NIH, DARPA and FDA Collaborate to Develop Cutting-edge Technologies to Predict Drug Safety,[sep 16th 2011], http://www.nih.gov/news/health/sep2011/od-16.htm
49. [49]
  49 Webtin Fabre, Proceedings of FAST Congress, Boston, Nov.1 Kris 7, 201449 Webtin Fabre, Proceedings of FAST Congress, Boston, Nov.1 Kris 7, 2014
50. [50]
  50 Ye N N, Qin J H, Shi W W, Liu X, Lin B C. Lab Chip, 2007, 7(12):1696-170450 Ye N N, Qin J H, Shi W W, Liu X, Lin B C. Lab Chip, 2007, 7(12):1696-1704
51. [51]
  51 Liu T J, Lin B C, Qin J H. Lab Chip, 2010, 10(13):1671-167751 Liu T J, Lin B C, Qin J H. Lab Chip, 2010, 10(13):1671-1677
52. [52]
  52 Li Y C, Qin, J H, Lin B C, Zhang W G. Tissue Eng. C, 2010, 16(6):1267-127552 Li Y C, Qin, J H, Lin B C, Zhang W G. Tissue Eng. C, 2010, 16(6):1267-1275
53. [53]
  53 LIN Bing-Cheng. Proceedings of the Xiangshan Conferences, 2010.11.09 林炳承. 香山会议文集, 2010.11.0953 LIN Bing-Cheng. Proceedings of the Xiangshan Conferences, 2010.11.09 林炳承. 香山会议文集, 2010.11.09
54. [54]
  54 Li E, Xu Z Y, Hui Z, Sun Z, Wang L, Guo Z, Zhao Y, Gao Z C, Wang Q. Oncotarget, 2015, 6(11):8900-891354 Li E, Xu Z Y, Hui Z, Sun Z, Wang L, Guo Z, Zhao Y, Gao Z C, Wang Q. Oncotarget, 2015, 6(11):8900-8913
55. [55]
  55 Zhou M Y, MaH P, Lin H L, Qin J H. Biomaterials, 2014, 35(5):1390-140155 Zhou M Y, MaH P, Lin H L, Qin J H. Biomaterials, 2014, 35(5):1390-1401
56. [56]
  56 LIN Hong-Li. Proceedings of the Shenzhen/Dalian Bilateral Conference on Microfluidics and Commercialization Strategy, 2015:23-24 林洪丽. 深圳-大连微流控芯片及其产业化战略研讨会文集, 2015:23-2456 LIN Hong-Li. Proceedings of the Shenzhen/Dalian Bilateral Conference on Microfluidics and Commercialization Strategy, 2015:23-24 林洪丽. 深圳-大连微流控芯片及其产业化战略研讨会文集, 2015:23-24
57. [57]
  57 JIN D, MA X C, LUO Y, FANG S M, XIE Z R, LI X J, QI D Y, ZHANG F Y, KONG J, LI J, LIN B C, LIU T J. RSC Advances, accepted57 JIN D, MA X C, LUO Y, FANG S M, XIE Z R, LI X J, QI D Y, ZHANG F Y, KONG J, LI J, LIN B C, LIU T J. RSC Advances, accepted
58. [58]
  58 KONG J, LUO Y, JIN D, AN F, ZHANG W Y, LIU L L, LI J, FANG S M, LI X J, LIU T, WANG Y Z, ZHAO Y Z, YANG X S, LIN B C, LIU T J. Oncotarget, accepted58 KONG J, LUO Y, JIN D, AN F, ZHANG W Y, LIU L L, LI J, FANG S M, LI X J, LIU T, WANG Y Z, ZHAO Y Z, YANG X S, LIN B C, LIU T J. Oncotarget, accepted
59. [59]
  59 An F, Qu Y Y, Luo Y, Fang N, Liu Y, Gao Z G, Zhao W J, Lin B C. SCI REP. Accepted59 An F, Qu Y Y, Luo Y, Fang N, Liu Y, Gao Z G, Zhao W J, Lin B C. SCI REP. Accepted
60. [60]
  60 Ho C M B, Ng S H, Li K H H, Yoon Y J. Lab Chip, 2015, 15(18):3627-363760 Ho C M B, Ng S H, Li K H H, Yoon Y J. Lab Chip, 2015, 15(18):3627-3637
61. [61]
  61 Spivey E C, Xhemalce B, Shear J B, Finkelstein I J. Anal. Chem., 2014, 86(15):7406-741261 Spivey E C, Xhemalce B, Shear J B, Finkelstein I J. Anal. Chem., 2014, 86(15):7406-7412
62. [62]
  62 Kolesky D B, Truby R L, Gladman A, Busbee T A, Homan K A, Lewis J A. Adv. Mater., 2014, 26(19):3124-313062 Kolesky D B, Truby R L, Gladman A, Busbee T A, Homan K A, Lewis J A. Adv. Mater., 2014, 26(19):3124-3130
63. [63]
  63 Bertassoni L E, Cecconi M, ManoharanV, Nikkhah M, Hjortnaes J, Cristino A L, Barabaschi G, Demarchi D, Dokmeci M R, Yang Y Z,Khademhosseini A. Lab Chip, 2014, 14(13):2202-221163 Bertassoni L E, Cecconi M, ManoharanV, Nikkhah M, Hjortnaes J, Cristino A L, Barabaschi G, Demarchi D, Dokmeci M R, Yang Y Z,Khademhosseini A. Lab Chip, 2014, 14(13):2202-2211
64. [64]
  64 Point of Care Testing based on Microfluidics:Player consolidationis inevitable! http://www.i-micronews.com/medtech/6841-point-of-care-testing-based-on-microfluidics-player-consolidation-is-inevitable.html?utm_source=communication.yole.fr&utm_medium=email&utm_campaign=articlerelaunch_BRO_MicroluidicsApplications_, 03 February 201664 Point of Care Testing based on Microfluidics:Player consolidationis inevitable! http://www.i-micronews.com/medtech/6841-point-of-care-testing-based-on-microfluidics-player-consolidation-is-inevitable.html?utm_source=communication.yole.fr&utm_medium=email&utm_campaign=articlerelaunch_BRO_MicroluidicsApplications_, 03 February 2016
65. [65]
  65 ZHANG Guo-Hao. Proceedings of the Shenzhen/Dalian Bilateral Conference on Microfluidics and Commercialization Strategy, 2015:39 张国豪. 深圳-大连微流控芯片及其产业化战略研讨会文集, 2015:3965 ZHANG Guo-Hao. Proceedings of the Shenzhen/Dalian Bilateral Conference on Microfluidics and Commercialization Strategy, 2015:39 张国豪. 深圳-大连微流控芯片及其产业化战略研讨会文集, 2015:39
66. [66]
  66 YE Jia-Ming. Proceedings of the Shenzhen/Dalian Bilateral Conference on Microfluidics and Commercialization Strategy, 2015:38 叶嘉明. 深圳-大连微流控芯片及其产业化战略研讨会文集, 2015:3866 YE Jia-Ming. Proceedings of the Shenzhen/Dalian Bilateral Conference on Microfluidics and Commercialization Strategy, 2015:38 叶嘉明. 深圳-大连微流控芯片及其产业化战略研讨会文集, 2015:38
67. [67]
  67 Wilfried von Eiff, Impact of POCT Technology on efficiency and effectiveness of clinical processes. http://www.moleculardxeurope.com/point-of-care-dx/67 Wilfried von Eiff, Impact of POCT Technology on efficiency and effectiveness of clinical processes. http://www.moleculardxeurope.com/point-of-care-dx/
68. [68]
  68 YoleReport, 2016.1.15 "Sample Preparation Automation Through Emerging Microfluidic Technologies" Nov.2015, http://www.i-micronews.com/component/hikashop/product/sample-preparation-automation-through-emerging-microfluidic-technologies-report-2015.html#description68 YoleReport, 2016.1.15 "Sample Preparation Automation Through Emerging Microfluidic Technologies" Nov.2015, http://www.i-micronews.com/component/hikashop/product/sample-preparation-automation-through-emerging-microfluidic-technologies-report-2015.html#description
69. [69]
  69 The Economist-Bioengineering, Towards a Body-on-a-chip,(Jun 13th 2015), http://www.economist.com/news/science-and-technology/21654013-first-organ-chips-are-coming-market-and-regulators-permitting-will-speed69 The Economist-Bioengineering, Towards a Body-on-a-chip,(Jun 13th 2015), http://www.economist.com/news/science-and-technology/21654013-first-organ-chips-are-coming-market-and-regulators-permitting-will-speed

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