微流控技术应用于细胞分析的研究进展

引用本文: 庄琪琛, 宁芮之, 麻远, 林金明. 微流控技术应用于细胞分析的研究进展[J]. 分析化学, 2016, 44(4): 522-532. doi: 10.11895/j.issn.0253-3820.160003 shu

Citation: ZHUANG Qi-Chen, NING Rui-Zhi, MA Yuan, LIN Jin-Ming. Recent Development in Microfluidic Chips for in vitro Cell-based Research[J]. Chinese Journal of Analytical Chemistry, 2016, 44(4): 522-532. doi: 10.11895/j.issn.0253-3820.160003 shu

微流控技术应用于细胞分析的研究进展

庄琪琛 ^1, ,
宁芮之 ^1,2, ,
麻远 ^1, ,
林金明 ^{1,
,}

1.
¹ 清华大学化学系, 微量分析测试方法和仪器研制北京市重点实验室生物有机磷化学和化学生物重点实验室, 北京 100084;
2.
² 东京大学大学院, 农学生命科学研究科, 东京 113-8657, 日本

通讯作者: 林金明

基金项目:
本文系国家自然科学基金(Nos.81373373,21227006,21435002) (Nos.81373373,21227006,21435002)

国家"211工程"项目"高等学校仪器设备和优质资源共享系统"(No.CERS-1-75)资助 (No.CERS-1-75)

摘要: 微流控技术由于其固有的优势已发展成为细胞分析中一个强有力的工具。本文从微流控芯片上的细胞培养、细胞微环境的模拟和控制、单细胞分析、芯片器官以及微流控芯片与质谱联用技术等方面对微流控技术在细胞分析研究中的应用进展进行了介绍,并对这一技术的发展前景进行了总结和展望,希望能为相关研究的开展提供启发。

关键词:

English

Recent Development in Microfluidic Chips for in vitro Cell-based Research

1.
¹ Department of Chemistry, Beijing Key Laboratory of Microanalytical Methods and Instrumentation, The Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Tsinghua University, Beijing 100084, China;
2.
² Department of Biomaterial Sciences, The University of Tokyo, Tokyo 113-8657, Japan

Corresponding author: 林金明

Received Date: 03 January 2016
Fund Project:
本文系国家自然科学基金(Nos.81373373,21227006,21435002)

国家"211工程"项目"高等学校仪器设备和优质资源共享系统"(No.CERS-1-75)资助

Abstract: Microfluidic technology has become a powerful tool in cell-based research due to its inherent advantages. The research progress of cell culture on chips, simulation and manipulation of cell microenvironment on chips, single cell analysis on chips, organ-on-a-chip, and chip-mass spectrometry technology was introduced in this review. Morover, the summary and prospect on the microfluidic technology were introduced to give some insights for researchers who were interested in developing microfluidic platforms for cell-based research.

Key words:

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沈阳化工大学材料科学与工程学院沈阳 110142

微流控技术应用于细胞分析的研究进展

通讯作者: 林金明

English

Recent Development in Microfluidic Chips for in vitro Cell-based Research

Corresponding author: 林金明

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中国化学会秘书处

微流控技术应用于细胞分析的研究进展

通讯作者: 林金明

English

Recent Development in Microfluidic Chips for in vitro Cell-based Research

Corresponding author: 林金明

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

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CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs