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芳酰腙和麦芽酚混合配体钒(Ⅴ)配合物的合成、表征、晶体结构及其类胰岛素活性

贺淼 ,  焦庆祝 ,  陈相飞 ,  李健 ,  陈杰 ,  盛桂华 ,  由忠录

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引用本文: 贺淼, 焦庆祝, 陈相飞, 李健, 陈杰, 盛桂华, 由忠录. 芳酰腙和麦芽酚混合配体钒(Ⅴ)配合物的合成、表征、晶体结构及其类胰岛素活性[J]. 无机化学学报, 2015, 31(8): 1590-1596. doi: 10.11862/CJIC.2015.174 shu
Citation:  HE Miao, JIAO Qing-Zhu, CHEN Xiang-Fei, LI Jian, CHEN Jie, SHENG Gui-Hua, YOU Zhong-Lu. Syntheses, Characterization, Crystal Structures and Insulin-Like Activity of Vanadium(Ⅴ) Complexes with Aroylhydrazone and Maltol Mixed-Ligands[J]. Chinese Journal of Inorganic Chemistry, 2015, 31(8): 1590-1596. doi: 10.11862/CJIC.2015.174 shu

芳酰腙和麦芽酚混合配体钒(Ⅴ)配合物的合成、表征、晶体结构及其类胰岛素活性

  • 1.

    1. 辽宁师范大学化学化工学院, 大连 116029;

  • 2.

    2. 山东理工大学生命科学学院, 淄博 255049

    • 通讯作者: 焦庆祝,E-mail:jiaoqz@163.com;由忠录,E-mail:youzhonglu@126.com; 焦庆祝,E-mail:jiaoqz@163.com;由忠录,E-mail:youzhonglu@126.com
  • 基金项目:

    辽宁省高校优秀青年人才支持计划(No.LR2014032)资助项目。 (No.LR2014032)

摘要: 制备了2个钒配合物[VOLL1] (1)和[VOLL2] (2),其中L为N'-(3,5-二溴-2-羟基苯甲基)-3-甲基苯甲酰肼,L1为甲基麦芽酚,L2为乙基麦芽酚。通过物理化学方法和单晶X-射线衍射对配合物的结构进行了表征。在每个配合物中,钒原子都是由来自配体L中的3个配位原子,来自L1或L2中的2个配位原子,以及1个氧基配体进行配位的,形成八面体配位构型。将配合物通过灌胃对正常的大鼠和四氧嘧啶糖尿病大鼠给药2周时间,结果表明这2个配合物在剂量为10.0和20.0 mgV·kg-1时可以显著降低四氧嘧啶糖尿病大鼠的血糖值,而正常大鼠的血糖值却没有改变。

English

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  • 收稿日期:  2015-04-16
  • 网络出版日期:  2015-04-23
通讯作者: 陈斌, bchen63@163.com
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