A rhodamine derivative for Hg2+-selective colorimetric and fluorescent sensing and its application to in vivo imaging

Xue-Mei Li Rui-Rui Zhao Yu-Ling Wei Dan Yang Zhang-Jian Zhou Jun-Feng Zhang Ying Zhou

引用本文: Xue-Mei Li,  Rui-Rui Zhao,  Yu-Ling Wei,  Dan Yang,  Zhang-Jian Zhou,  Jun-Feng Zhang,  Ying Zhou. A rhodamine derivative for Hg2+-selective colorimetric and fluorescent sensing and its application to in vivo imaging[J]. Chinese Chemical Letters, 2016, 27(6): 813-816. doi: 10.1016/j.cclet.2016.04.001 shu
Citation:  Xue-Mei Li,  Rui-Rui Zhao,  Yu-Ling Wei,  Dan Yang,  Zhang-Jian Zhou,  Jun-Feng Zhang,  Ying Zhou. A rhodamine derivative for Hg2+-selective colorimetric and fluorescent sensing and its application to in vivo imaging[J]. Chinese Chemical Letters, 2016, 27(6): 813-816. doi: 10.1016/j.cclet.2016.04.001 shu

A rhodamine derivative for Hg2+-selective colorimetric and fluorescent sensing and its application to in vivo imaging

  • 基金项目:

    This work was supported by the fund of China Tobacco Yunnan Industrial Co. (No. 2015JC05), the Foundation of the Department of Science and Technology of Yunnan Province of China (Nos. 2013HB062, 2014HB008), and Training Project (No. XT412003) of Yunnan University.

摘要: A rhodamine-based sensor has been developed for the detection of mercuric ions. The colorimetric and fluorescence responses, allowing naked-eye detections, are based on Hg2+-induced opening of the rhodamine spirocycle. Among all the testes ions, only Hg2+ generated a significant fluorescence enhancement of up to 30'-fold, with a bright yellow-green emission. This sensor was a low toxic compound, and was successfully applied in the in vivo imaging of Hg2+ in Spill 2 cells and C. elegans. This approach provides a sensitive and accurate method for the estimation of Hg2+ in environmental, tobacco and biological applications.

English

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  • 收稿日期:  2016-02-02
  • 修回日期:  2016-03-15
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