A pyridoxal-based chemosensor for visual detection of copper ion and its application in bioimaging

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A pyridoxal-based chemosensor for visual detection of copper ion and its application in bioimaging

Cai-Xia Yin , Li-Jun Qu , Fang-Jun Huo

Citation: Cai-Xia Yin, Li-Jun Qu, Fang-Jun Huo. A pyridoxal-based chemosensor for visual detection of copper ion and its application in bioimaging[J]. Chinese Chemical Letters, 2014, 25(9): 1230-1234. doi: 10.1016/j.cclet.2014.06.017 shu

shu

A pyridoxal-based chemosensor for visual detection of copper ion and its application in bioimaging

通讯作者: Fang-Jun Huo,

基金项目:
The work was supported by the National Natural Science Foundation of China (No. 21102086) (No. 21102086)

the Shanxi Province Foundation for Returnee (No. 2012-007) (No. 2012-007)

the Taiyuan Technology Star Special (No. 12024703) (No. 12024703)

Middle-aged Innovative Talents of Higher Learning Institutions of Shanxi (TYMIT, No. 2013802) (TYMIT, No. 2013802)

talents Support Program of Shanxi Province (No. 2014401) (No. 2014401)

CAS Key Laboratory of Analytical Chemistry for Living Biosystems Open Foundation (No. ACL201304). (No. ACL201304)

摘要: A pyridoxal-based chemosensor was synthesized by reacting hydrazine hydrate and pyridoxal hydrochloride in ethanol and characterized by NMR and ESI-MS. The optical properties of the compound were investigated in a methanol: HEPES solution. The compound displayed selectivity for Cu²⁺, as evidenced by a colorless to yellow color change, which was characterized using UV-vis spectroscopy. The fluorescence of the compound can be quenched only by Cu²⁺, accompanying by a color change from blue to colorless. Furthermore, it can be used in bioimaging.

关键词:

English

A pyridoxal-based chemosensor for visual detection of copper ion and its application in bioimaging

1.
a Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan 030006, China;
2.
b Research Institute of Applied Chemistry, Shanxi University, Taiyuan 030006, China

Corresponding author: Fang-Jun Huo,

Received Date: 31 March 2014
Fund Project:

Abstract: A pyridoxal-based chemosensor was synthesized by reacting hydrazine hydrate and pyridoxal hydrochloride in ethanol and characterized by NMR and ESI-MS. The optical properties of the compound were investigated in a methanol: HEPES solution. The compound displayed selectivity for Cu²⁺, as evidenced by a colorless to yellow color change, which was characterized using UV-vis spectroscopy. The fluorescence of the compound can be quenched only by Cu²⁺, accompanying by a color change from blue to colorless. Furthermore, it can be used in bioimaging.

Key words:

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