Nickel-catalyzed cross-coupling reaction of alkynyl bromides with Grignard reagents

Citation: Qing-Han Li, Yong Ding, Xue-Jun Yang. Nickel-catalyzed cross-coupling reaction of alkynyl bromides with Grignard reagents[J]. Chinese Chemical Letters, 2014, 25(9): 1296-1300. doi: 10.1016/j.cclet.2014.04.019 shu

Nickel-catalyzed cross-coupling reaction of alkynyl bromides with Grignard reagents

通讯作者: Qing-Han Li,

基金项目:
This work was financially supported by the Fundamental Research Funds for the Central Universities, Southwest University for Nationalities (No. 12NZYTH03) (No. 12NZYTH03)

the Natural Science Foundation of Southwest University for Nationalities (No. 381010) (No. 381010)

the Project of Postgraduate Degree Construction, Southwest University for Nationalities (No. 2013XWD-S0703) (No. 2013XWD-S0703)

the State Administration of Foreign Experts Affairs project (No. 2012-10). (No. 2012-10)

摘要: We describe a convenient method for the synthesis of 1,2-disubstituted acetylenes via a cross-coupling reaction of (bromoethynyl)benzene with Grignard reagents. The reaction of (bromoethynyl)benzene (1 mmol) with Grignard reagent (1.3 mmol) mediated by NiCl₂ (4 mol%) and (p-CH₃Ph)3P (8 mol%) in THF could produce 1,2-disubstituted acetylenes in good yields at room temperature.

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English

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