引用本文:
Jing Shan SHEN, Li Jun LEI, Hai Fang MAO, Jian Feng LI, Ru Yun JI. Synthesis of 5-Substituted Hexahydro-1H-1, 4-Diazepine Analogues[J]. Chinese Chemical Letters,
2001, 12(11): 951-954.
Citation: Jing Shan SHEN, Li Jun LEI, Hai Fang MAO, Jian Feng LI, Ru Yun JI. Synthesis of 5-Substituted Hexahydro-1H-1, 4-Diazepine Analogues[J]. Chinese Chemical Letters, 2001, 12(11): 951-954.
Citation: Jing Shan SHEN, Li Jun LEI, Hai Fang MAO, Jian Feng LI, Ru Yun JI. Synthesis of 5-Substituted Hexahydro-1H-1, 4-Diazepine Analogues[J]. Chinese Chemical Letters, 2001, 12(11): 951-954.
Synthesis of 5-Substituted Hexahydro-1H-1, 4-Diazepine Analogues
摘要:
5-Substituted hexahydro-1H-1,4-diazepine analogues were synthesized starting from N, N'-dibenzyl-1, 2-ethylenediamine and methyl 2, 4-dibromide butyrate through nucleophilic substitution, reduction, chlorination, debenzylation and amidation. Bioactivity tests showed that 9a had the highest agonist activity.
English
Synthesis of 5-Substituted Hexahydro-1H-1, 4-Diazepine Analogues
Abstract:
5-Substituted hexahydro-1H-1,4-diazepine analogues were synthesized starting from N, N'-dibenzyl-1, 2-ethylenediamine and methyl 2, 4-dibromide butyrate through nucleophilic substitution, reduction, chlorination, debenzylation and amidation. Bioactivity tests showed that 9a had the highest agonist activity.
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Key words:
- Substituted hexahydro-lH-1
- / 4-diazepine analogues
- / synthesis
- / bioactivity
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