引用本文:
Chuan Min QI, Zhi Zhong JI. SYNTHESIS AND POTENTIAL ANTINEOPLASTIC ACTIVITY OF α-(1-CYCLOPENTENYL) CYCLOPENTANONE DERIVATIVES-A NEW FAMILY OF ANTICANCER AGENTS[J]. Chinese Chemical Letters,
1995, 6(10): 847-850.
Citation: Chuan Min QI, Zhi Zhong JI. SYNTHESIS AND POTENTIAL ANTINEOPLASTIC ACTIVITY OF α-(1-CYCLOPENTENYL) CYCLOPENTANONE DERIVATIVES-A NEW FAMILY OF ANTICANCER AGENTS[J]. Chinese Chemical Letters, 1995, 6(10): 847-850.
Citation: Chuan Min QI, Zhi Zhong JI. SYNTHESIS AND POTENTIAL ANTINEOPLASTIC ACTIVITY OF α-(1-CYCLOPENTENYL) CYCLOPENTANONE DERIVATIVES-A NEW FAMILY OF ANTICANCER AGENTS[J]. Chinese Chemical Letters, 1995, 6(10): 847-850.
SYNTHESIS AND POTENTIAL ANTINEOPLASTIC ACTIVITY OF α-(1-CYCLOPENTENYL) CYCLOPENTANONE DERIVATIVES-A NEW FAMILY OF ANTICANCER AGENTS
摘要:
In search for anticancer agents,thirteen new α,β-unsaturated and β-aminomethyl cyclopentanones containing α-(1-cyclopentenyl) have been synthesized by condensation and by Mannich reaction respectively.Anticancer test showed that all title compounds have significant activities against P385,Hela.HepA and EAC in vitro.Part of these compounds were shown to have activity against EAC tumour in vivo.
English
SYNTHESIS AND POTENTIAL ANTINEOPLASTIC ACTIVITY OF α-(1-CYCLOPENTENYL) CYCLOPENTANONE DERIVATIVES-A NEW FAMILY OF ANTICANCER AGENTS
Abstract:
In search for anticancer agents,thirteen new α,β-unsaturated and β-aminomethyl cyclopentanones containing α-(1-cyclopentenyl) have been synthesized by condensation and by Mannich reaction respectively.Anticancer test showed that all title compounds have significant activities against P385,Hela.HepA and EAC in vitro.Part of these compounds were shown to have activity against EAC tumour in vivo.
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