引用本文:
孙立苹, 陈效, 杜予民. 羧甲基壳聚糖季铵盐的制备、表征及其对HeLa细胞的影响[J]. 应用化学,
2008, 25(6): 734-737.
Citation: SUN Li-Ping, CHEN Xiao, DU Yu-Min. Synthesis,Characterization of Quaternized Carboxymethyl Chitosan and its Effect on HeLa Cells[J]. Chinese Journal of Applied Chemistry, 2008, 25(6): 734-737.
Citation: SUN Li-Ping, CHEN Xiao, DU Yu-Min. Synthesis,Characterization of Quaternized Carboxymethyl Chitosan and its Effect on HeLa Cells[J]. Chinese Journal of Applied Chemistry, 2008, 25(6): 734-737.
羧甲基壳聚糖季铵盐的制备、表征及其对HeLa细胞的影响
English
Synthesis,Characterization of Quaternized Carboxymethyl Chitosan and its Effect on HeLa Cells
Abstract:
A new approach to preparation of chemically modified carboxymethyl chitosan (CM) derivatives was reported,where CM was prepared from chitosan with chloroactic acid as the carboxymethyl reagent first,and then N-quaternary ammonium group was introduced by the reaction of CM with 2,3-epoxypropyl trimethylammonium.The degree of substitution (DS) of carboxymethyl group was 0.73 and the DS of the quaternization group was 0.59.The mass-averaged molecular weight of CMQ was 1.1×104.The structures of the derivatives were characterized by FT-IR,XRD and 13C NMR.The effect of the CMQ on the human cervical carcinoma HeLa cells showed that CMQ can inhibit the proliferation and induce the apoptosis of HeLa cells.
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