引用本文:
尹汉东, 王传华, 洪敏. 丙酮酸异烟酰腙合锡(IV)配合物[Ph2Sn(C9H7N3O3)-(H2O)]2的合成、性质和晶体结构[J]. 应用化学,
2007, 24(10): 1124-1127.
Citation: YIN Han-Dong, WANG Chuan-Hua, HONG Min. Synthesis, Properties and Crystal Structure of Diorganotin(Ⅳ) Compound with Schiff Base Ligand Pyruvic Acid Isonicotinyl Hydrazone: [Ph2Sn(C9H7N3O3)-(H2O)]2[J]. Chinese Journal of Applied Chemistry, 2007, 24(10): 1124-1127.
Citation: YIN Han-Dong, WANG Chuan-Hua, HONG Min. Synthesis, Properties and Crystal Structure of Diorganotin(Ⅳ) Compound with Schiff Base Ligand Pyruvic Acid Isonicotinyl Hydrazone: [Ph2Sn(C9H7N3O3)-(H2O)]2[J]. Chinese Journal of Applied Chemistry, 2007, 24(10): 1124-1127.
丙酮酸异烟酰腙合锡(IV)配合物[Ph2Sn(C9H7N3O3)-(H2O)]2的合成、性质和晶体结构
摘要:
以丙酮酸异烟酰腙作为配体与二苯基氧化锡反应,制得新配合物[Ph2Sn(C9H7N3O3)-(H2O)]2。通过元素分析、红外光谱和核磁共振氢谱测试技术对其结构进行了表征,用X射线单晶衍射测定了化合物的晶体结构。该化合物晶体属正交晶系,空间群为P212121,晶胞参数a=1.1420(3) nm,b=1.1713(8) nm,c=3.520(2) nm,V=4.709(5) nm3,Z=4,μ=1.125 mm-1,Dc=1.501 Mg/m3,F(000)=2144,R=0.0745,wR=0.1704,GOF=1.015。测试结果表明,在配合物中锡原子处于七配位的五角双锥配位环境,配位原子分别来自1个三齿配体丙酮酸异烟酰腙负二价离子的2个O原子和1个N原子,1个水分子中的O原子,邻位配体中的1个O原子,以及来自于2个苯基的2个C原子,其中2个C原子占据了五角双锥的轴向位置。生物活性测试结果表明,化合物对MCF-7和WiDr均表现出较好的抑制作用。
English
Synthesis, Properties and Crystal Structure of Diorganotin(Ⅳ) Compound with Schiff Base Ligand Pyruvic Acid Isonicotinyl Hydrazone: [Ph2Sn(C9H7N3O3)-(H2O)]2
Abstract:
Diorganotin(Ⅳ) compound[Ph2Sn(C9H7N3O3)-(H2O)]2 was synthesized from the reaction of Ph2SnO with Schiff base ligand pyruvic acid isonicotinyl hydrazone. The compound was characterized by elemental analysis, IR, and 1H NMR, and the crystal structure was determined by X-ray single crystal diffraction. The crystal belongs to the orthorhombic system with space group P212121c, with a=1.142 0(3) nm, b=1.171 3(8) nm, c=3.520(2) nm, V=4.709(5) nm3, Z=4, μ=1.125 mm-1, Dc=1.501 Mg/m3, F(000)=2 144, R=0.074 5, wR=0.170 4, GOF=1.015. In this molecule, the Sn atom exists in a distorted pentagonal bipyramidal coordination environment in which one water molecule, one tridentate pyruvic acid isonicotinyl hydrazone ligand, and two trans P-cyanobenzyl groups coordinate to each Sn center, and the angle of the axial C10-Sn1-C18 is 166.1(2)°. The antitumor activity tests for the human tumor cell lines MCF-7 and WiDr show that this complex exhibits a good bioactivity.
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