引用本文:
李伟国, 赵大庆, 倪嘉缵. 一种钙/钙调蛋白依赖性的蛇毒磷脂酶A2[J]. 应用化学,
2001, 18(9): 682-684.
Citation: LI Wei Guo, ZHAO Da-Qing, NI Jia-Zuan. A Calcium/Calmodulin Dependent Phospholipase A_2 Obtained from Chinese Agkistrodon blomhoffii Ussurensis Venom[J]. Chinese Journal of Applied Chemistry, 2001, 18(9): 682-684.
Citation: LI Wei Guo, ZHAO Da-Qing, NI Jia-Zuan. A Calcium/Calmodulin Dependent Phospholipase A_2 Obtained from Chinese Agkistrodon blomhoffii Ussurensis Venom[J]. Chinese Journal of Applied Chemistry, 2001, 18(9): 682-684.
一种钙/钙调蛋白依赖性的蛇毒磷脂酶A2
English
A Calcium/Calmodulin Dependent Phospholipase A_2 Obtained from Chinese Agkistrodon blomhoffii Ussurensis Venom
Abstract:
The effects of calcium ion and rare earth ions on the activity of a phospholipase A2(PL2) obtained from Chinese Agkistrodon blomhoffii Ussurensis venom have been investigated.The results indicated that the activity of snake venom PLA2 is dependent on the concentration of calcium ion.Calmodulin(CAM), a calcium dependent regulator can also stimulate the activity of PLA2.La3+,Eu3+,Dy3+,Yb3+ showed different levels of inhibitory effects on the PLA2's activity mostly due to difference in ion radius.The relative activity of PLA2 inhibited by La3+ or Yb3+ at the concentration of 13.5μmol/L was 63.5% and 31.8%, respectively.
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Key words:
- phospholipase A2
- / calmodulin
- / rare earth ions
- / activity
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