引用本文:
杨智才, 张小微, 陈良. 手性铜催化剂的制备及在环丙烷羧酸酯不对称合成中的应用[J]. 应用化学,
1994, 11(2): 70-72.
Citation: Yang Zhicai, Zhang Xiaowei, Chen Liang. Chiral Copper Complexes for Asymmetric Synthesisof Cyclopropanecarboxylic Esters[J]. Chinese Journal of Applied Chemistry, 1994, 11(2): 70-72.
Citation: Yang Zhicai, Zhang Xiaowei, Chen Liang. Chiral Copper Complexes for Asymmetric Synthesisof Cyclopropanecarboxylic Esters[J]. Chinese Journal of Applied Chemistry, 1994, 11(2): 70-72.
手性铜催化剂的制备及在环丙烷羧酸酯不对称合成中的应用
English
Chiral Copper Complexes for Asymmetric Synthesisof Cyclopropanecarboxylic Esters
Abstract:
Three kinds of optically active ligands were combined with copper (Ⅱ)-acetate to give 8 chiral copper complexes:d-camphor-10-sulfonic acid and its derivatives of Schiff base,hydroxypinocamphone and its derivatives of Schiff base,and bis-oxazoline.The optical yields of 2,2-diphenylcyclopropanecarboxylic ethyl ester were 5%~50e.e..The reaction of diphenylethylene or isobutylene with menthyl diazoaceteta by chiral copper (Ⅱ) bis-oxazo-line gave an enantioselectivity of 81.5% e.e.and 95% e.e.,respectively.
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Key words:
- diazoacetate
- / diphenyl ethylene
- / isobutylene
- / cyclopropanation
- / camphorsulfonicacid
- / hydroxypinocamphone
- / bisoxazoline
- / chiral copper complex
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