引用本文:
蒋耀忠, 马有安, 陈振婉, 李广年. 固-液相转移催化合成——Ⅲ.α-甲基苯丙氨酸的合成及苄基化反应的研究[J]. 应用化学,
1987, 4(1): 44-47.
Citation: Jiang Yaozhong, Ma Youan, Chen Zhenwan, Li Guangnian. SOLID-LIQUID PHASE TRANSFER CATALYTIC SYNTHESIS Ⅲ.SYNTESIS OF α-METHYL PHENYLALANINE AND THE REACTION OF BENZYLATION[J]. Chinese Journal of Applied Chemistry, 1987, 4(1): 44-47.
Citation: Jiang Yaozhong, Ma Youan, Chen Zhenwan, Li Guangnian. SOLID-LIQUID PHASE TRANSFER CATALYTIC SYNTHESIS Ⅲ.SYNTESIS OF α-METHYL PHENYLALANINE AND THE REACTION OF BENZYLATION[J]. Chinese Journal of Applied Chemistry, 1987, 4(1): 44-47.
固-液相转移催化合成——Ⅲ.α-甲基苯丙氨酸的合成及苄基化反应的研究
摘要:
本文以丙氨酸甲酯和苯甲醛生成的西佛碱衍生物(1)为底物,进行固-液相转移催化苄基化反应,得到的苄基化产物(2)经酸水解合成了α-甲基苯丙氨酸,考察了相转移催化条件下苄基化反应的影响因素及动力学行为,该反应具有表面反应的特性及自催化反应的动力学特征,提出了固-液相转移催化反应的可能机理。
English
SOLID-LIQUID PHASE TRANSFER CATALYTIC SYNTHESIS Ⅲ.SYNTESIS OF α-METHYL PHENYLALANINE AND THE REACTION OF BENZYLATION
Abstract:
This paper reported the synthesis of α-methyl phenylalanine via benzylation of Schiff base (1) derived from alanine methyl ester with benzaldehyde and hydrolysis of (2) using solid-liquid phase transfer catalytic condition.The influencing factors and kinetics of benzylation of Schiff Base have been investigated. It was found that the reaction had the characteristic of surface reaction and autocatalytic reaction. A possible mechanism of solid-liquid phase transfer catalytic alkylation has been proposed.
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