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Citation: Zhu Zhenqi, Sun Qi'an, Ding Lan, Luo Guimin, Li Wei, Shen Jiacong. Synthesis and Characterizaion of Mimic Tripeptides with GPX Activity[J]. Chinese Journal of Applied Chemistry, ;1994, 11(6): 77-80. shu

Synthesis and Characterizaion of Mimic Tripeptides with GPX Activity

Zhu Zhenqi ¹ ,
Sun Qi'an ¹ ,
Ding Lan ¹ ,
Luo Guimin ¹ ,
Li Wei ² ,
Shen Jiacong ³

1.
1. The State Key Laboratory of Enzyme Engineering, Jilin University, Changchun 130023;
2.
2. Department of Molecnlar Biology, Jilin University, Changchun;
3.
2. Department of Chemistry, Jilin University

Received Date: 21 March 1994
Available Online: 12 July 1994

The alpha-amino and alpha-carboxyl group in glutamic acid (Glu) were protected by specific coprotection method,γ-Glu-Ser-Gly was synthesized by the liquid peptide method.The prepared mimic tripeptides were used for the chemical mutation of PMSF and H₂Se,as well as γ-Glu-SeCys-Gly,The structures of mimic tripeptides were determined by elemental analysis and amino acid analysis.The valency and quantity of Se in mimic tripeptides were determined.
- mimic tripeptide,
- GPX,
- synthesis,
- characterization
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