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Citation: LIU Jin-Gui, WANG Guo-Hui, DANG Shan. One-pot Synthesis of Novel Pyrazol-3,4-dihydropyrimidine[J]. Chinese Journal of Applied Chemistry, ;2009, 26(10): 1206-1210. shu

One-pot Synthesis of Novel Pyrazol-3,4-dihydropyrimidine

1.
College of Chemistry and Environmental Science, Henan Normal University, Xinxiang 453007

Corresponding author: LIU Jin-Gui,
Received Date: 14 October 2008
Available Online: 20 January 2009
Fund Project: 河南省教育厅自然科学基金(2006530008)资助项目 (2006530008)

Pyrazol-3,4-dihydropyrimidines were synthesized by one-pot Biginelli cyclocondensation of substituted-4-formylpyrazole,ethyl acetoacetate,urea or thiourea and ferric choride(in molar ratio of 1:3:3:1) in ethanol,under traditional heating or microwave irradiation conditions,while ferric chloride was used as a catalyst. The structures of all the products were characterized by elemental analysis,IR,¹H NMR and ¹³C NMR. The mechanism of the reaction and the spectra of all the compounds were also discussed. The method of microwave irradiation showed some advantages,such as a shorter reaction time and a higher yield,which is a new approach for synthesizing this kind of compounds.
- ferric chloride,
- Biginelli condensation,
- dihydropyrimidine,
- one-pot synthesis,
- microwave irradiation
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