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Citation: LI Bin-Dong, LV Chun-Xu. Synthesis of Sevoflurane in Ionic Liquids by Halogen-exchange Fluorination[J]. Chinese Journal of Applied Chemistry, ;2009, 26(9): 1126-1128. shu

Synthesis of Sevoflurane in Ionic Liquids by Halogen-exchange Fluorination

LI Bin-Dong ^, ,
LV Chun-Xu

1.
College of Chemical Engineering, Nanjing University of Science & Technology, Nanjing 210094

Corresponding author: LI Bin-Dong,
Received Date: 4 July 2008
Available Online: 20 December 2008

Sevoflurane was synthesized from 1,1,13,3,3-hexafluoro-2-(chloromethoxy)-propane by halogen-exchange in the presence of an ionic liquid as the solvent and a fluorinating agent.Mechanism of the phase transfer catalysis was discussed.The effects of [bpy]BF₄,[bmim]BF₄,[bepy]BF₄ and [bmim]PF₆ on the yield were investigated.The ionic liquid-water system and high surface area could not only induce KF to enter into the ionic liquid to produce high active F-but also reduce the formation of byproducts.The yield was 94.6%.The ionic liquid could be reused for three times without noticeable loss of activity.
- ionic liquid,
- sevoflurane,
- synthesis,
- potassium fluoride
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