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Citation: ZHANG Wen-sheng, KUANG Chun-Xiang. Microwave-induced One-pot Synthesis of 4-Ethynylbenzenesulfonamide[J]. Chinese Journal of Applied Chemistry, ;2009, 26(9): 1120-1122. shu

Microwave-induced One-pot Synthesis of 4-Ethynylbenzenesulfonamide

ZHANG Wen-sheng ^a,b ,
KUANG Chun-Xiang ^a,,

1.
a Department of Chemistry, Tongji University, Shanghai 200092;
2.
b Department of Chemistry, Jiaozuo Teachers’ College, Jiaozuo

Corresponding author: KUANG Chun-Xiang,
Received Date: 5 September 2008
Available Online: 30 October 2008
Fund Project: 上海市自然科学基金(06ZR14085) (06ZR14085)

One-pot simultaneous debrominative decarboxylation and sulfamation of anti-3-(4-chlorosulfonyl-benzyl)-2,3-dibromopropanoic acid and aqueous ammonia(2.2 mmol) in DMF under microwave irradiation for 25 s stereoselectively afforded intermediate(Z)-4-(2-brompvinyl) benzenesulfonamides.The intermediates,without isolation and purification,were treated with 1,8-diazabicyclo[5.4.0]undec-7-ene(DBU,2 mmol) under microwave irradiation for 1 min to give desired 4-ethynylbenzenesulfonamide in a yield of 70%.The structure of the product was identified by ¹H NMR,¹³C NMR and IR.
- sulfonamide,
- ethynylbenzene,
- one-pot,
- microwave irradiation
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