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Citation: Liu Keliang, He Binglin, Xiao Shaobo. SYNTHESIS OF 4-(N-SUBSTITUTED) AMINOMETHYL PHENYLALANINES[J]. Chinese Journal of Applied Chemistry, ;1990, 7(4): 72-74. shu

SYNTHESIS OF 4-(N-SUBSTITUTED) AMINOMETHYL PHENYLALANINES

1.
1. Institute of Polymer Chemistry, Nankai University, Tianjin 300071;
2.
2. Tianjin Municipal Research Institute for Family Palanning, Tianjin Medical College

Received Date: 21 August 1989
Available Online: 12 January 1990

The new 4-(-N-substituted) aminomethyl phenylalanines are presented. Dialkylamine rea-cted with N-acetyl-4-chloromethyl phenylalanine ethyl ester to give phenylalanine derivatives with basic side groups.After hydrolysis in hydrochloric acid and protection with Boc group the amino acids have been successfully used in solid phase peptide synthesis. This series amino acids combine basicity, aromaticity and hydrophilicity in the same molecule and have different N-dialkyl groups in length, they can be used in systematic research on structure-bioactivity relationships of peptides.
- 4-(N-dialkyl)aminomethyl phenylanaline,
- nopnrotein amino acid
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