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Citation: Li Yan, Huang Jinxia, Ma Xingquan, Chen Zuxing, Xu Zhanghuang. Synthesis of (3R,4R)-4-Methyl-3-heptanol[J]. Chinese Journal of Applied Chemistry, ;1999, 16(2): 76-78. shu

Synthesis of (3R,4R)-4-Methyl-3-heptanol

1.
Faculty of Chemistry and Material Science, Hubei University, Wuhan 430062

Received Date: 28 July 1998
Available Online: 23 November 1998
Fund Project:

(3R,4R)-4-Methyl-3-heptanol, the enatiomer of aggregation pheromone of the smaller European elm bark beetle (Scolytus Multistrialus), was stereoselectively synthesized using N-bornane-2,10-sultam as a chiral auxiliary. The two asymmetric carbon atoms of the target product were achieved by employing asymmetric syn-aldolization of N-propionylbornane-2,10-sultam (3) with propylaldehyde. The enantiomeric excess of (3R,4R)-4-methyl-3-heptanol prepared by this route is about 94.3%.
- (3R,4R)-methyl heptanol,
- European elm bark beetle,
- aggregation pheromone,
- asymmetric syn-aldolization,
- N-bornane sultam
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