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Citation: Xu Jiaxi, Wang Shuheng, Yi Youyun, Cai Mengshen. Studies on Antigenic Peptides of 26ku Glutathione S-Transferase of Schistosoma Japonicum[J]. Chinese Journal of Applied Chemistry, ;1999, 16(3): 37-40. shu

Studies on Antigenic Peptides of 26ku Glutathione S-Transferase of Schistosoma Japonicum

1.
a College of Chemistry and Molecular Engineering, Peking University, Beijing 100871;
2.
b Beijing Medical University, Beijing

Received Date: 15 September 1998
Available Online: 8 March 1999
Fund Project: 国家自然科学基金资助项目(29772002) (29772002)

Six antigenic peptides of 26ku glutathione S-transferase, Sj26, of Schistosoma japonicum have been predicted according to its hydrophilicity, flexibility, accessibility, charge distribution and β-turn in the secondary structure and synthesized. All of them showed good antigenicities by Dot-ELISA method with anti-Schistosoma japonicumim-immunoglobulin polyclonal antibody, anti-Sj-IgG PcAb. One also showed a good antigenicity for the anti-Schistosoma surface membrane monoclonal antibody, A6McAb. Two of them showed good protection rates in mouse. They would be as candidate peptides for synthetic peptide vaccine against schistosomiasis.
- Schistosoma japonicum,
- glutathione S-transferase,
- antigenic peptide,
- peptide vaccine
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