引用本文:
刘丽, 李晨曦, 何炳林. 生物降解高分子纳米球的制备[J]. 应用化学,
1999, 16(5): 69-72.
Citation: Liu Li, Li Chenxi, He Binglin. Preparation of Biodegradable Polymer Nanoshphere[J]. Chinese Journal of Applied Chemistry, 1999, 16(5): 69-72.
Citation: Liu Li, Li Chenxi, He Binglin. Preparation of Biodegradable Polymer Nanoshphere[J]. Chinese Journal of Applied Chemistry, 1999, 16(5): 69-72.
生物降解高分子纳米球的制备
摘要:
利用丙交酯的开环聚合反应合成了一系列聚乳酸(PLA)/聚乙二醇(PEG)/聚乳酸(PLA)三嵌段共聚物,采用1H NMR分析和测定了共聚物的组成和分子量.研究表明,当共聚物中PLA链段分子量相同时,共聚物薄膜的吸水量随着PEG链段分子量和PEG含量的增大而提高;在37℃、pH=7.4的磷酸缓冲溶液中,共聚物在60d内可基本降解完全.采用乳化溶剂蒸发技术制备了PLA/PEG/PLA三嵌段共聚物纳米球,其粒径受PLA链段及PEG链段分子量的影响,在103.6~141.6nm范围内,且大小均一,皆呈球形.
English
Preparation of Biodegradable Polymer Nanoshphere
Abstract:
Biodegradable triblock copolymers were prepared from d,l lactide and poly(ethylene glycol) by bulk ring opening polymerization. The compositions and molecular weights of the copolymers were determined by 1H NMR. Keeping the molecular weight of PLA segment constant, the water adsorption capacity of the copolymer films increased with the increase of the molecular weight and content of PEG segment in copolymer. The PLA/PEG/PLA triblock copolymer could be degraded in phosphate buffer solution(pH=7.4) at 37℃ in 60 days. The spherical copolymer nanospheres with narrow unimodal size distribution 103 6~141 6 nm were prepared by one step emulsion method. Their sizes were influenced by PLA chain length and PEG chain length.
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Key words:
- polylactide
- / poly(ethylene glycol)i
- / triblock copolymer
- / preparation
- / nanosphere
- / biodegradable polymer
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