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Citation: LI Zhen-Hua, PI Hong-Qiong, HE Bing-Lin. Preparation of Verapamil Hydrochloride-Resin Complexes and Their Drug Release Kinetics in vitro[J]. Chinese Journal of Applied Chemistry, ;2000, 17(1): 1-5. shu

Preparation of Verapamil Hydrochloride-Resin Complexes and Their Drug Release Kinetics in vitro

1.
State Key Laboratory of Functional Polymer Materials for Adsorption and Separation, Institute of Polymer Chemistry, Nankai University, Tianjin 300071

Received Date: 19 July 1999
Available Online: 29 November 1999
Fund Project: 国家教委博士点基金(98005504) (98005504)

The exchange reaction kinetics of verapamil hydrochloride(VH)w ith the strongly acidic cation exchange resin (001×7)and the release property of VH from the drug-resin complexes in deionic water, 0.5~2.0 mol/L NaCl and 0.5 mol/L HCl as well as 0.5 mol/L KCl solutions have been studied. It is found that the ex change rate increases with increase of temperature.The equilibrium constant of VH was 0.0527(298 K).The exchange reaction of VH with 001×7 was found to be controlled by particle diffusion process. The study of drug release in vitro showed that no VH release was found from drug-resin complexes in deionic water medium. The release rate increased with increase of ionic streng th of the release medium.The release of VH from drug-resin complexes could be effectively controlled by the strongly acidic cation exchange resin (001×7). The diffusion of VH within the resin particles was controlled by a particle diffusion process acco rding to Visw anathan's equation. The diffusion coefficients increased with the increase of the ionic streng th of the releasing media.
- verapamil hydrochloride,
- oral drug-resin controlled release system,
- exchange reaction kinetics,
- release kinetics
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