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Citation: DING Yu, YANG Guang-Fu. Syntheses and Fugicidal Activity of Flavanone Derivatives with Substitution in B Cycle[J]. Chinese Journal of Applied Chemistry, ;2001, 18(10): 785-789. shu

Syntheses and Fugicidal Activity of Flavanone Derivatives with Substitution in B Cycle

DING Yu ^a ,
YANG Guang-Fu ^a,b

1.
a Institute of Organic Synthesis, Central China Normal University, Wuhan 430079;
2.
b State Key Laboratory of Elemental Organic Chemistry, Nankai University, Tianjin

Received Date: 28 February 2001
Available Online: 25 June 2001
Fund Project: 国家自然科学基金(29802002) (29802002)教育部骨干教师资助计划,湖北省自然科学基金(98J045) (98J045)

In order to study the relationship between the fungicidal activity and the substituents on B cycle of flavanone derivatives, a series of flavanone derivatives containing various subtituents on B cycle were designed and synthesized starting from 2-hydroxylacetophenone. The structures of all compounds synthesized were confirmed by spectroscopic methods and microanalyses. Preliminary bioassays indicated that some compounds e.g. 3b, 3e, 3h and 3j showed excellent fungicidal activities against Rhizoctonia solani, Fusarium oxysporum, Physalospora piricola, Fusarium gramineum and Cercospora beticola at the dosage of 50 μg/L. Preliminary structure-activity relationship analysis indicated that the hydrophobicity and electronic effect of the substituents on B cycle have important effect on the fungicidal activity.
- flavanone,
- phytoalexins,
- synthesis,
- fungicidal activity,
- structure activity relation
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