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Citation: CHEN Min-Dong, YUAN Jian-Chao, LÜ Shi-Jie, DU Xiao-Li, YUAN Guang-Pu, YANG Shi-Yan. Synthesis and Antibacterial Activities of 1-Substituted Aryl-4-Ethoxycarbonyl-5-Acylamino-1,2,3-Triazoles[J]. Chinese Journal of Applied Chemistry, ;2001, 18(10): 772-776. shu

Synthesis and Antibacterial Activities of 1-Substituted Aryl-4-Ethoxycarbonyl-5-Acylamino-1,2,3-Triazoles

1.
a State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000;
2.
b Lanzhou Institute of Stook Farming and Veterinary Pharmacy Chinese Academy of Agricultural Sciences, Lanzhou

Received Date: 15 February 2001
Available Online: 31 May 2001
Fund Project: 国家自然科学基金资助项目(29933050) (29933050)

Twenty one new derivatives of 1-substituted aryl-4-ethoxy carbonyl-5-amino-1,2,3-triazole(compound 1) were obtained by reactions of 1-aryl-4-ethoxycarbonyl-5-amino-1,2,3-triazoles with benzoyl chloride, chloroacetyl chloride, propionyl chloride, acetyl chloride etc., in good yields(61%~91%). The relationships between yields and properties of acyl halides were discussed. The structures of all heterocyclic compounds were characterized by elemental analyses, IR, ¹H NMR and MS. Their antibacterial activities against Klebsiella, Escherichia coli, Pseudomonas aeruginosa, Staphlococcus aureus and Proteus vulgaris were screened.
- triazole,
- synthesis,
- antibacterial activity,
- acyl halide
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