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Citation: HU Juan, WEN Jing-Wei. Oscillographic Determination of Quinolone Antibiotics[J]. Chinese Journal of Applied Chemistry, ;2001, 18(12): 1009-1011. shu

Oscillographic Determination of Quinolone Antibiotics

HU Juan ^a ,
WEN Jing-Wei ^b

1.
a Department of Chemistry, Pingdingshan Normal College, Pingdingshan 467002;
2.
b Henan Institute of Medicine Inspection, Zhengzhou

Received Date: 29 March 2001
Available Online: 23 July 2001
Fund Project: 国家自然科学基金(29775018) (29775018)河南省教育厅自然科学基础研究项目(200053011)资助课题 (200053011)

Five quinolone antibiotics were determined by oscillographic chronopotentiometry, using a buffer solution of 0.20 mol/L KH₂PO₄-NaOH(pH=6.8). The sensitivity incisions for enoxacin(ENX), ciprofloxacin(CPLX), ofloxacin(OFLX), fleroxacin(FLRX) and sparfloxacin(SPLX) in result of redox reaction on the hang-Hg electrode were observed on the oscillograms at -1.31 V、-1.44 V、 -1.36 V、 -1.28 V、 -1.62 V, respectively. The incision heights were linearly proportional to the drug concentration respectively in the range of 7.35~64.2, 16.0~80.7, 4.00~36 7, 12.6~200.0, 9.8~83.4 mg/L with relative standard deviations of 0.7%~1.6%. The experiment results showed that quinolone antibiotics exhibited electrochemical activity. The method has advantages of simplicity, convenience and avoiding from interferences.
- quinolone antibiotics,
- determination,
- oscillographic chronopotentiometry
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