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Citation: LIN You Wen, LIN Qing, JIANG Zhi-Qing, ZHANG Wan-Chun, XU Chen. Preparation, Moisture Adsorbability and Retentivity of 2-Hydroxypropyltrimethyl Ammonium Chloride Chitosan[J]. Chinese Journal of Applied Chemistry, ;2002, 19(4): 351-354. shu

Preparation, Moisture Adsorbability and Retentivity of 2-Hydroxypropyltrimethyl Ammonium Chloride Chitosan

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a Department of Chemistry, Fujian Medical University, Fuzhou 350004;
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b Clinical Laboratory, Fujian Provincial People's Hospital, Fuzhou;
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c Institute of Polymer Science, Fujian Normal University, Fuzhou

Corresponding author: LIN You Wen,
Received Date: 8 August 2001
Available Online: 11 January 2002
Fund Project: 福建省教育厅科研基金资助项目(JA99184) (JA99184)

2-Hydroxypropyltrimethyl ammonium chloride chitosan(HACC), a water solube quaternary ammonium salt of chitosan, was prepared by the reaction of chitosan with 2,3-epoxypropyltrimethyl ammonium chloride. The content of quaternary cations(R₄N⁺) determined by the method of colloid titration with polyanion(PVSK) was 3.39 mmol/g, the content and degree of substitution of R₄N⁺ in N atom were 3.07 mmol/g and 58.1% respectively. IR spectra revealed that the most substituents were attached on N atom of chitosan. The moisture adsorbability of HACC was as good as that of hyaluronic acid(HA), the moisture retentivity of HACC was better than that of HA, the minimum inhibitory concentration(MIC) of HACC for staptytococous aureus(ATCC25293) was 625 mg/L.
- hydroxypropyltrimethyl ammonium chloride chitosan,
- preparation,
- moisture adsorbability,
- moisture retentivity,
- antibacterial activity
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