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Citation: YANG Song, SONG Bao-An, LI Zheng-Ming, LIAO Ren-An. Preparation of 2-(1H-Imidazol-1-yl)-1-(2,3,4-trimethoxyphenyl) ethanone[J]. Chinese Journal of Applied Chemistry, ;2002, 19(5): 491-493. shu

Preparation of 2-(1H-Imidazol-1-yl)-1-(2,3,4-trimethoxyphenyl) ethanone

1.
a Research and Development Centre of Fine Chemicals, Guizhou University, Guiyang 550025;
2.
b National Centre of Pesticide Engineering, Tianjin;
3.
c State Key Laboratory of Elemento-Organoic Chemistry, Nankai University, Tianjin

Corresponding author: SONG Bao-An,
Received Date: 23 June 2001
Available Online: 23 November 2001
Fund Project: 元素有机国家重点实验室开放基金(2002) (2002)国家自然科学基金(2946203) (2946203)贵州省优秀人才省长基金(20013)资助项目 (20013)

A new compound was synthesized with 1,2,3-trimethoxybenzene as the starting material, followed by acylation of Friedel Crafts, bromination reaction, the nucleophilic N-substitution of imidazole. For 2-bromo-1-(2,3,4-trimethoxyphenyl)ethanone in DMF,2-(1H-imidazol-1-yl)-1-(2,3,4-trimethoxyphenyl) ethanone was obtained in yield of 62.7%. It was obtained that the best reaction condition which the molar ratio of bromo compound to imidazole will be 1:5 and the reaction time will be 8 h under low temperature or room temperature. The structure of the product was confirmed by elemental analysis, ¹H NMR and IR spectrum analysis.
- trimethoxybenzene,
- 1H-imidazole,
- preparation
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