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Citation: XIAO Cong-Ming, ZHU Kang-Jie. Synthesis and in vitro Biodegradation of Poly(hexamethylene carbonate-co-sebacic anhydride)[J]. Chinese Journal of Applied Chemistry, ;2002, 19(5): 437-440. shu

Synthesis and in vitro Biodegradation of Poly(hexamethylene carbonate-co-sebacic anhydride)

XIAO Cong-Ming ^a,, ,
ZHU Kang-Jie ^b

1.
a Department of Material Science, Huaqiao University, Quanzhou 362011;
2.
b Department of Polymer Science, Zhejiang University, Hangzhou

Corresponding author: XIAO Cong-Ming,
Received Date: 8 August 2001
Available Online: 18 December 2001
Fund Project: 国家自然科学基金(59873019) (59873019)

Poly(hexamethylene carbonate-co-sebacic anhydride)s(PHCSA) containing aliphatic polycarbonate and labile anhydride groups was synthesized by copolymerization of diacid derived from oligo(hexamethylene carbonate)diol(OHCMD) with sebacic acid(SA) in mass ratios of 25:75, 50:50 and 75:25. The structure of PHCSA was confirmed by FTIR and ¹H NMR. The in vitro degradation of PHCSA was performed in 0.1 mol/L phosphate-buffer saline(PBS, pH 7-4) at 37℃. It was found that the degradation rate of PHCSA increased with the content of SA. After one-week degradation, the mass loss of PHCSA contained 80%, 58% and 32%(mole fraction) SA were 64.3%, 45.2% and 21.5% respectively. It was also found that the degradation of PHCSA could be catalyzed by lipase. After one week degradation in 1% lipase/PBS(0.1 mol/L, pH 7.4) at 37℃, the mass loss of PHCSA contained 58% and 32%(mole fraction) SA were 51.2% and 26.1% respectively. There was an obvious difference between the inner and the outer layer of samples in degradation. After two-week degradation, the M_w/M_w0 (ratio of final molecular weight to the initial molecular weight) of the inner layer and the outer layer of PHCSA contained 80%, 58% and 32%(mole fraction) SA were 89.9% and 27.9%, 98.1% and 39.1%, 97.8% and 47.2% respectively.
- poly(hexamethylene carbonate-co-sebacic anhydride),
- synthesis,
- in vitro biodegradation
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