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Citation: YUE Ke-Fen, ZHOU Chun-Sheng, GU Huan, SHI Zhen. Synthesis of p-Methylbenzaldehyde via Grignard Reagent[J]. Chinese Journal of Applied Chemistry, ;2002, 19(9): 905-907. shu

Synthesis of p-Methylbenzaldehyde via Grignard Reagent

1.
a Department of Chemistry, Northwest University, Xi'an 710069;
2.
b Department of Chemistry, Shangluo Nomal College, Shangzhou

Corresponding author: YUE Ke-Fen,
Received Date: 25 January 2002
Available Online: 17 May 2002
Fund Project: 国家自然科学基金(29872032) (29872032)西北大学青年基金(99NW47)资助项目 (99NW47)

p-Methylbenzaldehyde was prepared in yield of 75% by addition hydrolysis reactions of Grignard agent p-CH₃C₆H₄MgBr with 1,3-dimethylbenzimidazolium iodide. It is a biomimetic synthetic method. The reaction was carried out under mild and convenient condition. The addition reaction and hydrolysis were of "one-pot" reaction, without necessity of isolating benzimidazolidine. The hydrolysis reaction was carried out in 5% HCl solution at 30~40℃. The addition-hydrolysis reaction mechanism has been discussed briefly.
- p-methylbenzaldehyde,
- synthesis,
- dimethylbenzimidazolium idiode,
- Grignard reagent tolyl magnesium-bromide
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