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Citation: WANG Guo-Xi, PENG Cong-Hu. Synthesis of 5-Methoxyindole[J]. Chinese Journal of Applied Chemistry, ;2002, 19(10): 1014-1015. shu

Synthesis of 5-Methoxyindole

WANG Guo-Xi ^, ,
PENG Cong-Hu

1.
Department of Chemical Engineering, Anyang University, Anyang 455000

Corresponding author: WANG Guo-Xi,
Received Date: 5 February 2002
Available Online: 27 May 2002

5-Methoxyindole was synthesized in 4 steps starting from m-cresol through nitrosation oxidation, etherification, condensation and reduction-cyclization. The protecting piperidine group was at last removed from the enamine with Raney nickel as catalyst to give 5-methoxyindole. The total yield was 34.3%.
- methoxyindole,
- m-cresol,
- synthesis
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