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Citation: QI Jun-Sheng, CAO Yang, WANG Yuan-Liang. Selective Bromination of Paeonol with Copper(Ⅱ) Bromide[J]. Chinese Journal of Applied Chemistry, ;2003, 20(7): 702-703. shu

Selective Bromination of Paeonol with Copper(Ⅱ) Bromide

1.
a Department of Chemical Biology, Chongqing Three Gorges University, Chongqing 404000;
2.
b College of Bioengineering, Chongqing University, Chongqing 400044

Corresponding author: QI Jun-Sheng,
Received Date: 26 December 2002
Available Online: 29 April 2003
Fund Project: 科技部重点科技资助项目([2001]528001EP09001) ([2001]528001EP09001)重庆市教委自然基金资助([2001]12)项目 ([2001]12)

The selective bromination of paeonol (4-methoxy-2-hydroxyacetophenone) has been studied as function of solvents(methanol, ethanol, chloroform-ethyl acetate), reaction time, temperature and the mole ratio of reagents. The higher yield was obtained in polar solvents than in non-polar ones. The best solvent appeared methanol, and the mixtures of polar solvents were better than any single of them, except methanol. Paeonol and cupric bromide in mole ratio of 1:2 in methanol under reflux temperature for five hours gave a bromination product in yield of 63.3%.
- paeonol,
- selective bromination,
- copper(Ⅱ) bromide
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