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Citation: ZHONG Bin, FAN Zhi-Jin, LI Zheng-Ming. Synthesis and Biological Activity of 2-substituted Benzoxazole Derivatives[J]. Chinese Journal of Applied Chemistry, ;2003, 20(7): 684-686. shu

Synthesis and Biological Activity of 2-substituted Benzoxazole Derivatives

1.
Joint Institute of Nankai University and Tianjin University, State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071

Corresponding author: LI Zheng-Ming,
Received Date: 18 December 2002
Available Online: 31 March 2003
Fund Project: 国家"八六三"项目(2001AA235011)资助课题和教育部南开大学 (2001AA235011)

2-Mercapto benzoxazole reacted with alkyl halide or N-substituted-2-chloroacetamides gave corresponding 2-alkylthiobenzoxazoles(2a~2h) and benzoxazole-2-ylthio-acetanilides (3a~3g) respectively. The structures of all the above compounds were confirmed by ¹H NMR, IR and elemental analysis. Results showed that only compound 2g exhibited favorable fungicidal activity against Puccinia triticina(90%) in vivo at dosage of 500 mg/L; compounds 3a~3g exhibited inhibitory activity to Echinochloa oryzicola V and Brassica campestris L at the dosage of 150 mg/m².
- mercapto benzoxazole,
- synthesis,
- biological activity
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