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Citation: YU You-Zhu, ZHANG Jian-Chen, XU Jun, ZHAO Yu-Fen. Synthesis of N-Solanesyl-N,N'-bis(3,4-dimethoxybenzyl)ethylenediamine[J]. Chinese Journal of Applied Chemistry, ;2003, 20(8): 797-799. shu

Synthesis of N-Solanesyl-N,N'-bis(3,4-dimethoxybenzyl)ethylenediamine

YU You-Zhu ^a ,
ZHANG Jian-Chen ^a,, ,
XU Jun ^a ,
ZHAO Yu-Fen ^a,b

1.
a Department of Chemistry, Zhengzhou University, Zhengzhou 450052;
2.
b Department of Chemistry, Tsinghua University, Beijing

Corresponding author: ZHANG Jian-Chen,
Received Date: 18 December 2002
Available Online: 31 March 2003
Fund Project:

As a synergistic anti tumor agent, N-Solanesyl-N,N'-bis(3,4-dimethoxybenzyl) ethylenediamine(5) was synthesized starting from vanillin and solanesol. Methylation of vanillin gave veratradehyde(1), which after coupling with ethylenediamine was then catalytically reduced to N,N'-bis(3,4-dimethoxybenzyl) ethylenediamine(3), which was coupled with solanesol bromide (4) to give (5). The processes of synthesis of (3) and separation of (5) have been improved with total reaction yield being increased. The structures of the compounds were confirmed by IR, ¹H NMR, MS and elemental analysis.
- N-Solanesyl-N,N'-bis(dimethoxybenzyl) ethylenediamine,
- solanesyl bromide,
- antitumor agent,
- synthesis
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