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Citation: HU Ai-Xi, SHI Wen-Ge, WANG Xian-Feng, CHEN Ke. Chlorination of Arylalkyl Ketone with Cupric(Ⅱ) Chloride in Alcohol[J]. Chinese Journal of Applied Chemistry, ;2004, 21(2): 174-177. shu

Chlorination of Arylalkyl Ketone with Cupric(Ⅱ) Chloride in Alcohol

HU Ai-Xi ^a,, ,
SHI Wen-Ge ^b ,
WANG Xian-Feng ^a ,
CHEN Ke ^a

1.
a College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082;
2.
b Nanhua University, Hengyang

Corresponding author: HU Ai-Xi,
Received Date: 24 April 2003
Available Online: 24 April 2003
Fund Project: 湖南省科委重点资助课题(02962015) (02962015)

The chlorination of arylalkylketone has been carried out with cupric(Ⅱ) chloride in refluxing ethanol. For propiophenone, 3-chloropropiophenone and 6-methoxy-2-propionylnaphthalene the main products were α-monochlorinated compounds(2) and for 6-methoxy-2-acetylnaphthalene and 4-methoxy-acetophenone, α,α-dichlorinated products were formed. The structures of chlorinated products were characterized by ¹H NMR and MS spectral measurements.
- α-chlorination,
- propiophenone,
- chloropropiophenone,
- methoxy-propionyl-naphthalen,
- methoxy-acetylnaphthalene,
- methoxyacetophenone,
- cupric(Ⅱ)chloride
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