Home

Citation: YANG Yuan-Yuan, ZHOU Guo-Quan, CHEN Xin-Zhi. An Improved Synthesis of 4-Aminopyridine[J]. Chinese Journal of Applied Chemistry, ;2004, 21(5): 530-531. shu

An Improved Synthesis of 4-Aminopyridine

1.
College of Material Science and Chemical Engineering, Zhejiang University, Hangzhou 310027

Corresponding author: CHEN Xin-Zhi,
Received Date: 6 June 2003
Available Online: 31 December 2003

4-Cyanopyridine was at first catalytically hydrolyzed to give isonicotinamide in the presence of Mg-Fe oxides with yield 92%. 4-Aminopyridine was obtained from isonicotinamide in yield of 83%~85% by Hofmann reaction using iodo-benzene as catalyst. All of the reaction were monitored by TLC and the products were confirmed by IR, NMR and melting point determination.
- aminopyridine,
- cyanopyridine,
- Hofmann reaction,
- hydrolysis
1. [1]
  Qi Chen , Hanyi Li , Yu Gao , Yinan Yang , Jianhao Zhou , Suning Li . Application of a Programmable Heating Control System in Organic Chemistry Experiment. University Chemistry, 2026, 41(1): 310-320. doi: 10.12461/PKU.DXHX202506016
2. [2]
  Zhaoyang WANG , Chun YANG , Yaoyao Song , Na HAN , Xiaomeng LIU , Qinglun WANG . Lanthanide(Ⅲ) complexes derived from 4′-(2-pyridyl)-2, 2′∶6′, 2″-terpyridine: Crystal structures, fluorescent and magnetic properties. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1442-1451. doi: 10.11862/CJIC.20240114
3. [3]
  Qiaorong RU . Synthesis and characterization of tripyridine functionalized polyionic liquid luminescent materials. Chinese Journal of Inorganic Chemistry, 2026, 42(1): 111-119. doi: 10.11862/CJIC.20250121
4. [4]
  Yuxin LI , Mengqi ZHOU , Feifan LANG , Chunyan NI , Bing WU , Jianping LANG . Pyridine ligand-regulated structural diversity of W/Cu/S cluster-based supramolecules. Chinese Journal of Inorganic Chemistry, 2026, 42(7): 1429-1436. doi: 10.11862/CJIC.20260126
5. [5]
  Chenyang WANG , Yiyan BAI , Wei ZHANG , Zhaorong LIU , Yuchun WANG . Performance of photo-assisted copper oxide catalyzed hydrolysis of ammonia borane to produce hydrogen. Chinese Journal of Inorganic Chemistry, 2026, 42(1): 97-110. doi: 10.11862/CJIC.20250116
6. [6]
  Chengqian Mao , Yanghan Chen , Haotong Bai , Junru Huang , Junpeng Zhuang . Photodimerization of Styrylpyridinium Salt and Its Application in Silk Screen Printing. University Chemistry, 2024, 39(5): 354-362. doi: 10.3866/PKU.DXHX202312014
7. [7]
  Xiao SANG , Qi LIU , Jianping LANG . Synthesis, structure, and fluorescence properties of Zn(Ⅱ) coordination polymers containing tetra-alkenylpyridine ligands. Chinese Journal of Inorganic Chemistry, 2024, 40(11): 2124-2132. doi: 10.11862/CJIC.20240158
8. [8]
  Qiaowen CHANG , Ke ZHANG , Guangying HUANG , Nuonan LI , Weiping LIU , Fuquan BAI , Caixian YAN , Yangyang FENG , Chuan ZUO . Syntheses, structures, and photo-physical properties of iridium phosphorescent complexes with phenylpyridine derivatives bearing different substituting groups. Chinese Journal of Inorganic Chemistry, 2025, 41(2): 235-244. doi: 10.11862/CJIC.20240311
9. [9]
  Hongjie SHEN , Haozhe MIAO , Yuhe YANG , Yinghua LI , Deguang HUANG , Xiaofeng ZHANG . Synthesis, crystal structure, and fluorescence properties of two Cu(Ⅰ) complexes based on pyridyl ligand. Chinese Journal of Inorganic Chemistry, 2025, 41(5): 855-863. doi: 10.11862/CJIC.20250009
10. [10]
  Xiaotong LU , Pan ZHANG , Zijie ZHAO , Lei HUANG , Hongwei ZUO , Lili LIANG . Antitumor and antibacterial activities of pyridyl Schiff base indium and dysprosium complexes. Chinese Journal of Inorganic Chemistry, 2025, 41(8): 1523-1532. doi: 10.11862/CJIC.20250073
11. [11]
  Qiang HU , Zhiqi CHEN , Zhong CHEN , Xu WANG , Weina WU . Pyridinium-chalcone-based ClO^- fluorescent probe: Preparation and biological imaging applications. Chinese Journal of Inorganic Chemistry, 2025, 41(9): 1789-1795. doi: 10.11862/CJIC.20250086
12. [12]
  Huilin ZHENG , Tao WANG , Ruilin GAO , Mengke ZHOU , Xinyue LI , Hui WANG , Xiaoxia GU . Antitumor and antibacterial activities of transition metal complexes incorporating pyridyl salicylaldehyde Schiff base. Chinese Journal of Inorganic Chemistry, 2026, 42(5): 897-905. doi: 10.11862/CJIC.20250358
13. [13]
  Hongyu Cheng , Ruiyao Wang , Xingwen Sun . Mechanistic Study of the Classic Hofmann Elimination Reaction. University Chemistry, 2025, 40(12): 187-191. doi: 10.12461/PKU.DXHX202510104
14. [14]
  Yeyun Zhang , Zhenfeng Shang , Ling Fan . Green experimental improvement and ideological and political teaching design of the acid-catalyzed sucrose hydrolysis. University Chemistry, 2026, 41(6): 353-361. doi: 10.12461/PKU.DXHX202504040
15. [15]
  Yingying Wang , Yang Yu . 基于统计能量分析的酶催化机理探究：以丝氨酸水解酶为例. University Chemistry, 2026, 41(9): 373-381. doi: 10.12461/PKU.DXHX202508066
16. [16]
  Gengwei Zhang , Jun Cao . 化学反应动力学方程的AI辅助发现——以蔗糖水解反应为例. University Chemistry, 2026, 41(9): 396-404. doi: 10.12461/PKU.DXHX202508037
17. [17]
  Yingchun ZHANG , Yiwei SHI , Ruijie YANG , Xin WANG , Zhiguo SONG , Min WANG . Dual ligands manganese complexes based on benzene sulfonic acid and 2, 2′-bipyridine: Structure and catalytic properties and mechanism in Mannich reaction. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1501-1510. doi: 10.11862/CJIC.20240078
18. [18]
  Yi DING , Peiyu LIAO , Jianhua JIA , Mingliang TONG . Structure and photoluminescence modulation of silver(Ⅰ)-tetra(pyridin-4-yl)ethene metal-organic frameworks by substituted benzoates. Chinese Journal of Inorganic Chemistry, 2025, 41(1): 141-148. doi: 10.11862/CJIC.20240393
19. [19]
  Mengyu LI , Kewei TONG , Li ZHANG , Minghua LU , Abudula , Luwen ZHU , Yi LIU , Luying WANG , Baiqiao SONG , Zunqi LIU , Peng YANG , Yanhu WANG . Functionalizing the cavities of imidazolyl polyoxovanadate‒organic polyhedra with embedded pyridine to modulate iodine adsorption. Chinese Journal of Inorganic Chemistry, 2026, 42(9): 1974-1983. doi: 10.11862/CJIC.20260154
20. [20]
  Yukun Chang , Haoqin Huang , Baolei Wang . Preparation of Trans-Cinnamic Acid via “One-Pot” Protocol of Aldol Condensation-Hydrolysis Reaction: Recommending an Improved Organic Synthesis Experiment. University Chemistry, 2024, 39(4): 322-328. doi: 10.3866/PKU.DXHX202309095

Get Citation

PDF

XML

Metrics

PDF Downloads(1)
Abstract views(949)
HTML views(75)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Address：Zhongguancun North First Street 2,100190 Beijing, PR China Tel: +86-010-82449177-888

DownLoad: Full-Size Img PowerPoint

Return