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Citation: ZHANG Jing-Xia, PAN Shi-Rong, WANG Qin-Mei, HUANG Ai-Dong. Synthesis and Characteristics of Poly[N-(2-Hydroxyethyl)-L-Glutamine]-5-Fluorouracil-1-Acetic Acid[J]. Chinese Journal of Applied Chemistry, ;2004, 21(10): 1057-1059. shu

Synthesis and Characteristics of Poly[N-(2-Hydroxyethyl)-L-Glutamine]-5-Fluorouracil-1-Acetic Acid

1.
a Zhongshan Medical College, Sun Yat sen University, Guangzhou 510089;
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b The First Affiliated Hospital, Sun Yat sen University, Guangzhou 510089

Corresponding author: ZHANG Jing-Xia,
Received Date: 8 October 2003
Available Online: 10 March 2004
Fund Project: 广东省自然科学基金资助(031684)项目 (031684)

Coupling water soluble and biodegradable poly(N-(2-hydroxyethyl)-L-glutamine)(PHEG) synthesized from poly((γ-benzyl)-L-glutamine) and 2-aminoethanol with 5-fluorouracil-1-acetic acid(FUA) as a simulated drug affords a polymer prodrug poly(N-(2-hydroxyethyl)-L-glutamine)-5-fluorouracil-1 acetic acid(PHEG-FUA). The conjugation between the polymer and the drug compound has been confirmed by IR, UV, ¹H NMR and DSC. The content of 5 fluorouracil was determined to be about 26%(UV method). The in vitro test results show that the accumulated drug release amounts of PHEG FUA was 47.63% in phosphorus salt buffer solution (pH=7.2) during 120 h, indicating the conjugated compound has an obvious sustained release effect.
- poly[N-(hydroxyethyl)-L-glutamine]fluorouracil acetic acid,
- prodrug,
- sustained release
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