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Citation: QIAN Hong-Sheng, CHEN Li-Min, HU Wei-Xiao. Synthesis of 5-Methyl-7-methoxy-isoflavone[J]. Chinese Journal of Applied Chemistry, ;2005, 22(2): 224-226. shu

Synthesis of 5-Methyl-7-methoxy-isoflavone

1.
a College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310032;
2.
b New He Cheng Chemical Engineering Co. Ltd, Xinchang

Corresponding author: HU Wei-Xiao,
Received Date: 26 March 2004
Available Online: 26 July 2004

2,4-Dihydroxy-6-methyldeoxybenzoin synthesized from the Hoesch reaction of 3,5-dihydroxytoluene with benzyl cyanide was used to react with triethyl orthoformate by using morpholine as catalyst to form 5-methyl-7-hydroxy-isoflavone. The latter gave the title compound via O-methylation with dimethyl sulfate. The yields of the three steps were 55%, 87% and 56%, respectively. The total yield was about 26%.
- dihydroxymethyldeoxybenzoin,
- methylmethoxy-isoflavone,
- dihydroxytoluene,
- organic synthesis
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