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Citation: FENG Yi-Si, YANG Qing-Hua, HUANG Qing-Yun, YAO Ri-Sheng. Improvement on the Synthesis of Fork Glycerinol[J]. Chinese Journal of Applied Chemistry, ;2005, 22(4): 460-461. shu

Improvement on the Synthesis of Fork Glycerinol

1.
a School of Chemical Engineering, Hefei University of Technology, Hefei 230009;
2.
b Kelong Institute of Marteria Madeca, Hefei

Received Date: 14 August 2004
Available Online: 12 December 2004

The optical active fork glycerinol (2,2-dimethyl-1,3-dioxolane-4-methanol)(1) was synthesized with L-serine (2) as the starting material.L-glyceric acid (3) was synthesized via the nitrosation of (2).With TsOH as the catalyst and 4A molecular sieve as the dehydration agent,LM-2,3-O-isopropylidene-glycerate (5) was directly prepared from (3),2,2'-dimethoxypropane and methanol without isolating the intermediate.Instead of LiAlH₄,NaBH₄ was used to reduce (5) to the final compound (1).The total yield of was 47%.
- L-serine,
- synthesis,
- fork glycerinol,
- dimethoxypropane
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